BRAIN MYELIN INTEGRITY IN BIPOLAR DISORDER: AN IN VIVO MAGNETIC RESONANCE IMG

双相情感障碍中脑髓磷脂的完整性：体内磁共振 IMG

• 批准号: 7627540
• 负责人: JAIR C SOARES
• 金额: $ 1.79万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627540
• 关键词: Affect; Age; Anxiety Disorders; Axon; Bipolar Disorder; Brain; Brain region; Cerebral hemisphere; Chicago; Clinical; Communication; Computer Retrieval of Information on Scientific Projects Database; Computer software; Corpus Callosum; DSM-IV; Development; Diagnosis; Disease; Ethnic Origin; Female; Functional disorder; Funding; Gender; Grant; Hamilton Rating Scale for Depression; Hour; Image; Institution; Interview; Investigation; Israel; Magnetic Resonance; Magnetic Resonance Imaging; Manic; Measures; Medical; Mental disorders; Methods; Myelin; Nerve; Neurons; Patients; Persons; Pharmaceutical Preparations; Process; Protocols documentation; Psychiatric Diagnosis; Psychiatrist; Purpose; Rate; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Severities; Signal Transduction; Source; Standards of Weights and Measures; Structure; Substance abuse problem; Symptoms; System; Therapeutic Intervention; Time; United States National Institutes of Health; Water; Week; base; clinically relevant; concept; in vivo; inclusion criteria; male; myelination; neuropsychological; research clinical testing; size; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: Until recently, brain myelin and white matter have not been a major focus of investigation in bipolar patients. Myelin (the white matter insulating the nerves), and factors that affect myelination are processes that could profoundly affect neuronal connectivity. Anatomical magnetic resonance imaging (MRI) studies have shown increased rates of white matter hyperintensifies in bipolar disorder, which might be disrupting connectivity among the brain structures implicated in the pathophysiology of this disorder. Recently, reports indicating smaller size and decreased MRI signal intensity in specific sub-regions of corpus callosum (a white matter midline structure that connects the two brain hemispheres, allowing inter-hemispheric communication) in bipolar patients have appeared. These findings suggest the involvement of myelin and white matter abnormalities in the pathophysiology of bipolar disorder. The purpose of this study is to examine whether there are regional myelin abnormalities in white matter brain regions in bipolar patients. RESEARCH PLAN: We propose to utilize a new method to measure myelin integrity, based on the three-pool concept, which proposes that myelin segregates water fractions into myelin, myelinated axons, and mixed pools. The three-pool method successfully estimated the rate and onset of myelination in our preliminary studies. We will study a group of 30 untreated bipolar patients and 30 matched healthy controls, using a 1.9 Tesla MRI magnet. METHODS: We will recruit a group of 30 untreated bipolar patients and 30 healthy controls matched for age, gender and ethnicity, for a total of 60 persons, over a 2-year period, both male and female, ages 18-75. Inclusion criteria for bipolar patients are: a) DSM-IV diagnosis of bipolar disorder type I; b) no substance abuse within the past 6 months; c) no current medical problems; d) not receiving psychotropic medications for at least two weeks at the time of participation in the study; and e) no comorbid psychiatric disorders, except for Anxiety Disorders. Psychiatric diagnosis will be established according to the DSM-IV criteria, using the SCID-IV Interview, and confirmed subsequently in a clinical evaluation by a research psychiatrist. The Hamilton Depression Rating Scale - 17 items and the Young Mania Rating Scale will be used to rate the severity of clinical symptoms. A standard neuropsychological battery will be administered at the time of entrance in the protocol to investigate the possibility of neuropsychological deficits. All subjects will undergo a brain MRI scan, which is performed in a single session and takes 2 hours. All images will be acquired on a large-bore 1.9 T MRI system (Elscint, Haifa, Israel). Statistical analyses will be performed using SPSS version 11.5 software (SPSS, Inc., Chicago, IL). CLINICAL RELEVANCE: This study will investigate, for the first time, brain myelin integrity in bipolar disorder, and by doing so, contribute to understanding the disease mechanisms involved. It could ultimately result in the development of new and more effective therapeutic interventions for this disorder.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：直到最近，脑髓鞘和白色物质还没有成为双相情感障碍患者研究的主要焦点。 髓鞘（隔离神经的白色物质）和影响髓鞘形成的因素是可能深刻影响神经元连接的过程。 解剖磁共振成像（MRI）研究显示，双相情感障碍患者的白色物质过度强化率增加，这可能会破坏与该疾病病理生理学相关的大脑结构之间的连接。 最近，出现了双相情感障碍患者胼胝体（连接两个大脑半球的白色中线结构，允许半球间通信）特定子区域尺寸变小和MRI信号强度降低的报告。 这些发现表明髓鞘和白色物质异常参与双相情感障碍的病理生理学。本研究的目的是检查双相情感障碍患者的白色脑区是否存在局部髓鞘异常。 研究报告：我们建议利用一种新的方法来衡量髓鞘的完整性，基于三池的概念，提出髓鞘隔离水馏分成髓鞘，有髓鞘的轴突，和混合池。 在我们的初步研究中，三池法成功地估计了髓鞘形成的速率和发生。 我们将研究一组30名未经治疗的双相情感障碍患者和30名匹配的健康对照，使用1.9特斯拉MRI磁体。 方法：我们将招募一组年龄、性别和种族匹配的30名未经治疗的双相情感障碍患者和30名健康对照者，共计60人，为期2年，年龄18-75岁，男性和女性。 双相患者的入选标准是：a）DSM-IV诊断为双相障碍I型; B）在过去6个月内没有药物滥用; c）当前没有医学问题; d）在参与研究时至少两周没有接受精神药物治疗;以及e）没有共病精神障碍，焦虑障碍除外。 精神病诊断将根据DSM-IV标准，使用SCID-IV访谈建立，并随后由研究精神病学家在临床评估中确认。 将使用汉密尔顿抑郁评定量表-17项和杨氏躁狂评定量表评定临床症状的严重程度。 在方案中，将在入组时进行标准神经心理成套测试，以研究神经心理缺陷的可能性。 所有受试者将接受脑部MRI扫描，该扫描在单次会议中进行，需要2小时。 所有图像将在大口径1.9 T MRI系统（Elscint，Haifa，Israel）上采集。 将使用SPSS 11.5版软件（SPSS，Inc.，芝加哥，IL）。 临床相关性：这项研究将首次调查双相情感障碍患者的脑髓鞘完整性，并通过这样做，有助于了解所涉及的疾病机制。 它可能最终导致开发新的和更有效的治疗干预这种疾病。