SEVEN DAYS OF EXOGENOUS PULSATILE GNRH, PITUITARY GONADAL AXIS/HYPOGONADOTROPIC

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案的总体目标是研究生殖的控制，并更好地了解促性腺激素释放激素(GnRH)在人类男性生殖中的作用。在这项研究中，对患有GnRH缺乏(也称为Kallmann综合征)的男性进行了为期7天的脉动性GnRH治疗，并测量了激素的变化。这提供了有关个体对GnRH反应的信息，并为我们进一步研究这种疾病的遗传原因提供了重要信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this protocol is to investigate the control of reproduction and to better understand the role of gonadotropin-releasing hormone (GnRH) in human male reproduction. In this study, men with GnRH deficiency (also known as Kallmann syndrome) are treated with pulsatile GnRH for 7 days and hormonal changes are measured. This provides information about an individual's response to GnRH and provides important information for our additional study looking into the genetic causes of this disease.