Training Program in Reproductive & Developmental Biology

描述(由申请者提供)：全国普遍缺乏经过翻译培训的年轻调查人员，包括博士和医学博士。为了实现这一目标，马萨诸塞州总医院的生殖与发育生物学培训计划从丰富的候选人库中挑选积极的候选人；为学员提供基础和/或临床研究方面的深入研究经验；为这些努力提供技术熟练且资金充足的从事重要研究问题的教员；并通过在遗传学、生殖和发育生物学以及临床研究的基础科学方面的丰富教学经验来补充这种指导研究经验。选拔受训者的依据是：以前的学术和研究成就；对未来学术事业的坚定承诺；以及表明他们作为独立调查人员的动机和未来潜力的个人面试。PI(Crowley博士)是哈佛医学院医学教授、哈佛生殖内分泌科学中心主任、知名科学家和公认的导师，与担任联席主任的高素质资深科学家Patricia Donahoe博士共同管理。培训人员由活跃的、资金充足的科学家组成，他们的专业知识涵盖了从基础发育生物学到床边调查的所有生殖和发育研究。这项提议扩大了培训人员，以反映并适当利用正在重新定义翻译研究的新工具和机会。每个实习生都受到一个积极的、个性化的指导计划的密切监督，该计划由一名资深教员监督。广泛而严格的教学计划与他们强大的、独立的实验室计划紧密交织在一起，并赞扬了学员2-3年的研究经验(90%的努力)。培训期通常包括作为初级教员的额外年限，以确保为后续的独立支持提供最大的竞争力，这是本培训计划的最终目标。研究设施宽敞，设备齐全，配备了最近现代化的实验室和临床研究空间，专门用于该基金的培训教师。制度环境一流，生殖内分泌科学中心项目的强化是实质性的。这一机构培训赠款是这些计划中的关键稳定因素，也是使有才华的受训人员能够在生殖和发育生物学领域实现后续独立职业生涯的关键环节。

DESCRIPTION (provided by applicant): There is a widely acknowledged national shortage of translationally trained young investigators, both Ph.D.s and M.D.s. To accomplish this goal, the Reproductive & Developmental Biology Training Program at the Massachusetts General Hospital selects strongly motivated candidates from a rich candidate pool; provides trainees with an intensive research experience in basic and/or clinical investigation; supports these efforts with a skilled and well-funded faculty engaged in important research questions; and complements this mentored research experience by a strong didactic experience in the underpinning sciences of genetics, reproductive and developmental biology and clinical investigation. Trainees are selected on the basis of prior academic and research accomplishments; a strong future commitment to an academic career; and a personal interview indicating their motivation and future potential as independent investigators. The PI (Dr. Crowley) is a Professor of Medicine at Harvard Medical School, Director of the Harvard Reproductive Endocrine Sciences Center, an established scientist and recognized mentor who governs in conjunction with Dr. Patricia Donahoe, a highly qualified senior scientist, who serves as Co-Director. The training faculty consists of active, well-funded scientists whose expertise lines the full spectrum of reproductive and developmental research from fundamental developmental biology to bench-to-bedside investigations. The training faculty has been expanded in this proposal to reflect and take appropriate advantage of the new tools and opportunities that are redefining translational research. Each trainee is closely supervised by an active yet individualized mentorship program overseen by a senior faculty member. An extensive and rigorous didactic program interlaces tightly with their strong, independent laboratory programs and compliments the trainees' 2-3 years of research experience (90%effort). The training period often involves additional years as junior faculty to ensure maximal competitiveness for subsequent independent support, the ultimate goal of this Training Program. Research facilities are spacious and fully equipped with recently modernized laboratory and clinical research space dedicated to the training faculty of this grant. The institutional environment is superb and the reinforcement from the Reproductive Endocrine Sciences Centers programs is substantial. This institutional training grant represents a critical stabilizing element in these programs and is a critical link that enables talented trainees to achieve subsequent independent careers in Reproduction and Developmental Biology.