SEVEN DAYS OF EXOGENOUS PULSATILE GNRH, PITUITARY GONADAL AXIS/HYPOGONADOTROPIC

七天外源性脉动 GNRH、垂体性腺轴/促性腺激素低下

• 批准号: 7731228
• 负责人: William Francis Crowley
• 金额: $ 0.34万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731228
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Genetic; Goals; Gonadotropin Hormone Releasing Hormone; Grant; Hormonal Change; Individual; Institution; Kallmann Syndrome; Measures; Protocols documentation; Reproduction; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; day; hormone deficiency; human male; men; pituitary gonadal axis; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this protocol is to investigate the control of reproduction and to better understand the role of gonadotropin-releasing hormone (GnRH) in human male reproduction. In this study, men with GnRH deficiency (also known as Kallmann syndrome) are treated with pulsatile GnRH for 7 days and hormonal changes are measured. This provides information about an individual's response to GnRH and provides important information for our additional study looking into the genetic causes of this disease.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本方案的总体目标是研究生殖的控制，并更好地了解促性腺激素释放激素（GnRH）在人类男性生殖中的作用。 在这项研究中，患有GnRH缺乏症（也称为卡尔曼综合征）的男性接受脉冲式GnRH治疗7天，并测量激素变化。 这提供了关于个体对GnRH反应的信息，并为我们进一步研究这种疾病的遗传原因提供了重要信息。