THE EFFECT OF EXERCISE ON CORONARY HEMODYNAMICS

运动对冠状动脉血流动力学的影响

• 批准号: 7625756
• 负责人: Lawrence I Sinoway
• 金额: $ 0.22万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625756
• 关键词: Animals; Blood; Blood flow; Bypass; Chest; Computer Retrieval of Information on Scientific Projects Database; Coronary; Coronary artery; Data; Dobutamine; Doppler Ultrasound; Exclusion Criteria; Exercise; Funding; Grant; Heart Diseases; Institution; Invasive; Ischemia; Left; Measurement; Measures; Mediating; Monitor; Morbidity - disease rate; Norepinephrine; Pilot Projects; Property; Regulation; Research; Research Personnel; Resources; Role; Sampling; Source; Stress; Techniques; Time; United States National Institutes of Health; Venous; design; hemodynamics; human subject; internal thoracic artery; non-invasive monitor; renal artery; response; vasoconstriction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary: This is pilot study to evaluate the role of exercise in regulation of coronary artery blood flow. Although studies in animals have shown that sympathetically mediated coronary vasoconstriction occurs during static contraction, there is little data evaluating coronary flow response to exercise in human subjects. Historically the need for invasive flow monitoring has made it difficult to study real-time coronary hemodynamics during exercise. Recent studies using non-invasive trans-thoracic Doppler ultrasound demonstrated similar flow properties in LIMA (left internal mammary artery) bypass grafts and coronary arteries, suggesting this approach may allow non-invasive monitoring of coronary hemodynamics. The investigators propose to use this technique in 15 subjects that have undergone LIMA bypass grafting within the past 5 years to study the effect of handgrip exercise on coronary artery flow. Exclusion criteria are designed to exclude subjects with cardiac disease or co-morbidities that may alter coronary flow. A dobutamine stress echo will be performed to exclude subjects with significant coronary ischemia. Real-time ultrasound Doppler measurements of mean blood velocity will be performed in the LIMA left internal mammary artery graft and renal arteries during voluntary and involuntary handgrip exercise, and during handgrip and post-handgrip ischemia. Venous norepinephrine (NE) levels will be measured at baseline, and following the exercise paradigms (4 samples/subjects).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 项目概述：这是一项初步研究，旨在评估运动在调节冠状动脉血流中的作用。尽管动物研究表明交感神经介导的冠状动脉血管收缩发生在静态收缩期间，但很少有数据评估人类受试者对运动的冠状动脉血流反应。从历史上看，对有创血流监测的需要使得难以研究运动期间的实时冠状动脉血流动力学。 最近使用无创经胸多普勒超声的研究表明，LIMA（左乳内动脉）的血流特性相似 旁路移植物和冠状动脉，表明这种方法可以允许冠状动脉血流动力学的非侵入性监测。 研究人员建议在过去5年内接受LIMA旁路移植术的15名受试者中使用该技术，以研究握力运动对冠状动脉血流的影响。 排除标准旨在排除患有可能改变冠状动脉血流的心脏病或合并症的受试者。 将进行多巴酚丁胺负荷超声心动图检查，以排除严重冠状动脉缺血的受试者。将在LIMA左乳内动脉中进行平均血流速度的实时超声多普勒测量 移植物和肾动脉在自愿和非自愿的握手运动，并在握手和握手后缺血。 将在基线和运动模式后（4份样本/受试者）测量静脉去甲肾上腺素（NE）水平。