GENERAL CLINICAL RESEARCH CENTER M01 RR12248

普通临床研究中心 M01 RR12248

• 批准号: 7074389
• 负责人: ALLEN M. SPIEGEL
• 金额: $ 253.66万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7074389
• 关键词: GENERAL; CLINICAL; RESEARCH; CENTER; M01

The Einstein-Montefiore GCRC has benefited from the augmentation of clinical research nationally as well as from Institutional investments that have permitted expansion in its scope and innovation. Our per diem GCRC provides platforms and tools to sustain a diverse portfolio of research spanning diabetes, epilepsy, aging, and reproductive physiology, to sickle cell anemia, HIV/AIDS, CVD, and cancer. In our current project period, we successfully implemented 2 state-of-the-art Cores, one a high-field Magnetic Resonance (MR) Research Core, and the second an Analytic Core Laboratory providing mass spectrometry and other analyses. Our training efforts have not only yielded new K12 and K23 investigators who use the GCRC for their projects, but have also integrated the GCRC with the training mission of the College of Medicine. The GAC and the RSA have collaborated with the IRBs to put data and safety monitoring guidelines into practice, and we have implemented secure research informatics management. In the aggregate, the GCRC has experienced dramatic outpatient visit increases in the past two years, and our investigators have been highly productive; thus, the current application includes 60 projects, -50% more than in our previous application with a total of over $55 million in Federal research grant support. The Principal Investigator of the GCRC is Dominick Purpura, MD, Dean of the College of Medicine, and its Program Director is Harry Shamoon, MD, Associate Dean for Clinical Research. Drs. Ronald Nagel and Sanjeev Gupta will continue as Associate Program Directors. Jullie Pan MD, PhD and Daniel Stein, MD are directors of the MR and the Analytic Cores, respectively, and Hillel Cohen, DrPH continues as GCRC Biostatistician. Margaret Arnim, MBA is the Administrative Director. Owing to the success of our GCRC in supporting clinical investigation, the Institution is completing a second outpatient GCRC facility and laboratory adjacent to the new Children's Hospital at Montefiore that will increase capacity and provide a (heretofore unavailable) site for pediatric clinical research. The GCRC is at the focal point of the Institution's Strategic Plan for clinical and translational research that includes constructing a $200-million Center for Genetic and Translational Medicine, recruiting clinical investigators, developing innovative research training and career development, and facilitating new scientific endeavors. Based on our track record, we hope this application demonstrates that our GCRC merits further investment. In keeping with growth of the Center, we request support for an expanded leadership including Associate Program Directors for Pediatrics (Frederick Kaskel MD,PhD), Research Training (Paul Marantz MD,MPH), and Neurology (Shlomo Shinnar MD,PhD), and also for the additional personnel and resources to enable this much-needed expansion.

爱因斯坦-蒙特菲奥里GCRC受益于全国临床研究的加强以及 来自允许其范围和创新扩大的机构投资。我们的每日GCRC 提供平台和工具，以支持涵盖糖尿病、癫痫、衰老和 生殖生理学、镰状细胞性贫血、艾滋病毒/艾滋病、心血管疾病和癌症。在我们目前的项目期内，我们 成功实施了2个最先进的核心，其中一个是高场磁共振(MR)研究核心， 第二个是分析核心实验室，提供质谱分析和其他分析。我们的培训 努力不仅产生了新的K12和K23调查员，他们在他们的项目中使用GCRC，而且 还将GCRC与医学院的培训任务结合起来。GAC和RSA拥有 与IRBs合作，将数据和安全监测指南付诸实践，我们已经实施了 确保研究信息管理的安全性。总体而言，GCRC经历了戏剧性的门诊访问 在过去两年中有所增加，我们的调查人员工作效率很高；因此，目前的应用程序 包括60个项目，比我们之前的申请增加了50%，联邦政府的总投资超过5500万美元 研究资助。GCRC的首席研究员是多米尼克·普尔普拉，医学博士，学院院长 其项目主任是临床研究副院长哈里·沙文医学博士。戴维斯博士。 罗纳德·内格尔和桑吉夫·古普塔将继续担任副项目主任。朱莉·潘，医学博士和丹尼尔 Stein，MD分别是MR和Analytic Core的董事，Hillel Cohen，DrPH继续担任 GCRC生物统计学家。玛格丽特·阿尼姆，MBA，行政总监。由于我们的成功 在支持临床研究方面，该机构正在完成第二个门诊GCRC设施，并 毗邻蒙特菲奥里新儿童医院的实验室将增加容量并提供 (迄今为止不可用)儿科临床研究的地点。GCRC是该研究所的中心 临床和转化研究战略计划，包括建设一个2亿美元的基因研究中心 和转化医学，招聘临床研究人员，发展创新研究培训和职业生涯 发展，并促进新的科学努力。根据我们的过往记录，我们希望这项申请 证明我们的GCRC值得进一步投资。为配合中心的发展，我们要求 支持扩大领导层，包括儿科副项目主任(弗雷德里克·卡斯克尔) 医学博士)，研究培训(Paul Marantz医学博士，公共卫生硕士)和神经学(Shlomo Shinnar医学博士，博士)，以及 需要更多的人员和资源来实现这一亟需的扩张。