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End organ damage in children with primary hypertension

原发性高血压儿童的终末器官损害

基本信息

批准号：
7667498
负责人：
DEBORAH P JONES
金额：
$ 10.8万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-27 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7667498
关键词：
10 year old Adolescence Adolescent Adult Aftercare Age Albumins Ambulatory Blood Pressure Monitoring Area Atherosclerosis Biology Biometry Birth Weight Blood Pressure Blood Vessels Cardiac Cardiovascular Diseases Cardiovascular system Categories Child Childhood Clinical Clinical Research Data Detection Development Diagnosis Diastolic blood pressure Dietary Sodium Environment Epidemiology Essential Hypertension Evaluation Evolution Excretory function Family history of Family member Fetal Growth Retardation First Degree Relative Future Gender Genetic Goals Heart Height Hypertension Individual Insulin Resistance Kidney Kidney Diseases Knowledge Left Left Ventricular Mass Life Longitudinal Studies Low Birth Weight Infant Measurement Measures Mediating Medical Metabolic syndrome Methods Monitor Obesity Organ Outcome Measure Participant Pattern Perinatal Peripheral Physiologic pulse Physiology Prevention Price Reading Research Personnel Resolution Risk Risk Factors Sleep Stratification Thick Time Training Variant Vasodilation Ventricular Weight awake base brachial artery cardiovascular disorder prevention cardiovascular risk factor clinical application clinically relevant follow-up hypertension prevention improved indexing innovation insight intima media kidney vascular structure offspring population based programs salt intake skills tool urinary

项目摘要

DESCRIPTION (provided by applicant): Hypertension is a significant risk factor for cardiovascular and renal disease. Familial and longitudinal studies demonstrate that adult hypertension may begin in late childhood and adolescence. Although the majority of children under the age of ten years have some form of underlying renal disease, primary hypertension is the most common cause of elevated BP in the second decade of life. Risk factors for childhood essential hypertension include obesity, family members with hypertension, insulin resistance, low birth weight or intrauterine growth retardation and liberal dietary sodium. Therefore, it seems intuitive that prevention of adult cardiovascular disease should begin during childhood. In addition, the presence of hypertension has a major impact on the individual with underlying renal disease. Diagnosis of hypertension in children currently depends on casual BP readings as compared to population-based distribution curves rather than outcome measures. Recently, ambulatory BP monitoring (ABPM) has become a useful clinical tool to more carefully characterize diurnal BP patterns. Not only can the mean systolic and diastolic BP be measured, the percentage of elevated readings and awake to sleeping decline can be assessed. In addition, there is a need for more sensitive markers of target organ damage. Whereas increased left ventricular mass and microalbumin excretion are clinically relevant measures of target organ damage, detection of subtle, potentially reversible vascular changes are postulated to be present prior to overt cardiac or renal damage. The candidate has pursued the area of childhood hypertension for the past 3 years and intends to complete formal training in epidemiology and medical biostatistics to strengthen her clinical research skills. Combined with a focus on vascular biology, the candidate plans to interface current knowledge in the area of renal physiology and vascular biology with innovative clinical applications in an effort to further define the underlying mechanisms of childhood hypertension with the eventual goal of prevention of hypertension induced renal and cardiovascular damage.

描述（由申请人提供）：