HU/JHU Head and Neck Cancer Translational Research and *

描述（由申请人提供）： 头颈癌是全球第六大常见癌症，在美国是第七大常见实体瘤。非裔美国男性的头颈癌发病率比非裔美国男性高约两倍，5年相对生存率较低（36.2% vs. 47.6%）。霍华德大学医疗机构是一个少数民族服务的教育机构和医疗中心，是在华盛顿/巴尔的摩大都市区的重要教育和临床资源，并为低收入的非洲裔美国人患者的大型社区服务。然而，招聘和支持转化研究工作在霍华德大学有重大的挑战。本提案的目标是通过霍华德大学医疗机构和约翰霍普金斯医疗机构头颈癌中心之间的高度合作，创造一个合作环境，以加强霍华德大学医疗机构头颈癌相关的转化研究和教育。这项合作的重点是转化研究和研究培训以及教育工作，重点是加强头颈癌转化研究和对霍华德医疗机构社区的影响。具体目标是：1）支持霍华德大学医疗机构与约翰霍普金斯大学头颈部癌症中心和西德尼·金梅尔癌症中心之间的合作癌症研究项目2）提供合作培训和指导计划，以促进霍华德医学和牙科学生和教师在癌症研究中的参与，3）建立教育计划，促进转化癌症研究的知识，因为它适用于病因学，在为少数群体服务的机构中预防、诊断和治疗头颈癌。这些目标将以协同方式促进和协调，从而加强霍华德大学癌症中心内合作转化研究文化的创建，以及与约翰霍普金斯医疗机构研究人员的有效长期合作伙伴关系。这些目标将通过对霍华德医疗机构的个人的指导来实现，以通过国家癌症研究所的传统机制发展为独立的研究者。

DESCRIPTION (provided by applicant): Head and neck cancer is the sixth most common cancer worldwide, the seventh most common solid tumor in the United States. The incidence of head and neck cancer in African American men has been approximately two times higher than that of non African American men with a lower 5-year relative survival (36.2% vs. 47.6%). Howard University Medical Institutions is a minority-serving educational institution and medical center that is an important educational and clinical resource in the Washington DC/ Baltimore metropolitan area and serves a large community of low-income African American patients. However, recruitment and support for translational research efforts at Howard University has significant challenges. The goal of this proposal is to create a collaborative environment to enhance translational research and education related to head and neck cancer at the Howard University Medical Institutions through a highly collaborative effort between the Howard University Medical Institutions and the Head and Neck Cancer Center at the Johns Hopkins Medical Institutions. This collaboration is focused on translational research and research training as well as educational efforts focused on enhancing head and neck cancer translational research and impact on the Howard Medical Institutions community. Specific aims will be: 1) to support collaborative cancer research projects between the Howard University Medical Institutions and the Head and Neck Cancer Center and Sidney Kimmel Cancer Center at Johns Hopkins 2) to provide collaborative training and mentoring program for promoting Howard medical and dental students and faculty in cancer research, 3) to establish education programs that advance the knowledge of translational cancer research as it applies to etiology, prevention, diagnosis, and treatment of head and neck cancer in the context of minority-serving institutions. These aims will be promoted and coordinated in a synergistic manner, such that they reinforce the creation of a culture of collaborative translational research within the Howard University Cancer Center as well as an effective long-term partnership with investigators at the Johns Hopkins Medical Institutions. These goals will be pursued by directed mentorship of individuals at Howard Medical Institutions to develop as independent investigators via traditional mechanisms of the National Cancer Institute.