AVIAN IMMUNE RESPONSE TO INFECTIOUS DISEASE

禽类对传染病的免疫反应

• 批准号: 7598410
• 负责人: BABETTA L MARRONE
• 金额: $ 2.1万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598410
• 关键词: Agriculture; Arts; Biological Markers; Bird Diseases; Birds; Chickens; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; DNA Damage; Detection; Disease; Droughts; Early Diagnosis; Environment; Environmental Monitoring; Environmental Pollution; Flow Cytometry; Foundations; Funding; Grant; Health; Health Resources; Human; Immune response; Institution; Measures; Mission; Molecular; Monitor; Parasites; Physiological; Population; Research; Research Personnel; Resources; Risk Reduction; Sampling; Science; Sentinel; Social Welfare; Source; System; United States National Institutes of Health; West Nile virus; base; biosafety level 3 facility; environmental stressor; innovation; new technology; pathogen; response; vector transmission

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Birds are a key transmission vector and host to human infectious diseases and are susceptible to environmental contaminants, drought, and other environmental stressors that can disrupt normal physiological functions without causing avian disease. These factors make avian populations excellent sentinel systems for monitoring potential threats to human health and resources from the predicted 30 new zoonotic diseases in the next few decades. A prime example is the current use of captive sentinel chickens to monitor the emergence of West Nile Virus (WNV). However, a major drawback to the use of birds as sentinels has been the lack of a strong science-based approach that would allow the detection of disease before it has progressed into the human population. The main objective of this proposal is to build a scientific foundation for developing an advanced state-of the-art sentinel biosurveillance system based on detection of early biomarkers of health in avian populations that are relevant to agents in the environment that also threaten human health and welfare. This project builds upon unique resources at Los Alamos including an established Avian Nestbox Network currently used as part of an ongoing mission in environmental monitoring and risk reduction; combined with the National Flow Cytometry Resource, and the new Biosafety Level-3 facility. The approach will be to develop a panel of new technologies for sampling and measuring functional immune response, DNA damage, and pathogen and parasite loads in birds. An expert team of avian ecologists, molecular microbiologists, and technologists has been assembled. The major product will be an innovative, sensitive, and accurate panel of biomarkers for measuring responses in the field. The biomarker panel will enable an entirely new capability with potential far-reaching impact on our nations ability to detect and forecast emerging threats to human health, agriculture, and wildlife.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 鸟类是关键的传播载体，并寄托着人类传染病，并且容易受到环境污染物，干旱和其他环境压力源的影响，这些疾病可能会破坏正常生理功能而不会引起禽类疾病。 这些因素使鸟类种群在未来几十年中从预测的30种新的人畜共患病中监测对人类健康和资源的潜在威胁的出色哨兵系统。 一个主要的例子是目前使用圈养前哨鸡来监测西尼罗河病毒（WNV）的出现。但是，使用鸟类作为哨兵的主要缺点是缺乏强大的基于科学的方法，该方法可以在疾病发展到人口之前就可以发现疾病。 该提案的主要目的是建立一个科学基础，以开发基于对与环境中的特工有关的鸟类健康和福利的代理相关的早期健康生物标志物的检测，以开发先进的前哨生物监视系统。 该项目以洛斯阿拉莫斯（Los Alamos）的独特资源为基础，其中包括既定的鸟巢网络，目前用作环境监测和降低风险的持续任务的一部分；结合国家流式细胞仪资源和新的生物安全3级设施。 该方法将是开发一组新技术，用于采样和测量鸟类中的功能免疫反应，DNA损伤以及病原体和寄生虫负荷。 组装了鸟类生态学家，分子微生物学家和技术人员的专家团队。主要产品将是一种创新，敏感和准确的生物标志物，用于测量现场的反应。 生物标志物小组将实现全新的能力，对我们国家检测和预测对人类健康，农业和野生动植物的新兴威胁的能力潜在深远影响。