P-GLYCOPROTEIN AND CYTOCHROME P450 GENOTYPE AND PHENOTYPE ON RESPONSE TO ANCA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定某些CYP450酶和特定药物转运体的遗传组成是否对预测对环磷酰胺和糖皮质激素治疗的反应(就改善肾功能而言)具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to determine whether genetic make-up of certain CYP450 enzymes and a particular drug transporter are significant to predicting responses (in terms of improved kidney function) to cyclophosphamide and glucocorticoid therapy.