P-GLYCOPROTEIN AND CYTOCHROME P450 GENOTYPE AND PHENOTYPE ON RESPONSE TO ANCA

P-糖蛋白和细胞色素 P450 基因型和表型对 ANCA 的反应

• 批准号: 7716797
• 负责人: MELANIE S JOY
• 金额: $ 0.35万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716797
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cyclophosphamide; Cytochrome P450; Enzymes; Funding; Genetic; Genotype; Glucocorticoids; Glycoproteins; Grant; Institution; Pharmaceutical Preparations; Phenotype; Purpose; Renal function; Research; Research Personnel; Resources; Source; United States National Institutes of Health; improved; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to determine whether genetic make-up of certain CYP450 enzymes and a particular drug transporter are significant to predicting responses (in terms of improved kidney function) to cyclophosphamide and glucocorticoid therapy.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定某些CYP 450酶和特定药物转运蛋白的遗传组成是否对预测环磷酰胺和糖皮质激素治疗的反应（在改善肾功能方面）具有重要意义。