P-GLYCOPROTEIN AND CYTOCHROME P450 GENOTYPE AND PHENOTYPE ON RESPONSE TO ANCA

P-糖蛋白和细胞色素 P450 基因型和表型对 ANCA 的反应

• 批准号: 7716797
• 负责人: MELANIE S JOY
• 金额: $ 0.35万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716797
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cyclophosphamide; Cytochrome P450; Enzymes; Funding; Genetic; Genotype; Glucocorticoids; Glycoproteins; Grant; Institution; Pharmaceutical Preparations; Phenotype; Purpose; Renal function; Research; Research Personnel; Resources; Source; United States National Institutes of Health; improved; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to determine whether genetic make-up of certain CYP450 enzymes and a particular drug transporter are significant to predicting responses (in terms of improved kidney function) to cyclophosphamide and glucocorticoid therapy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是确定某些CYP450酶和特定药物转运蛋白的遗传组成是否对预测对环磷酰胺和糖皮质激素治疗的反应（在肾脏功能改善方面）是否重要。