Modulating inflammation as a therapy for Harlequin Ichthyosis

调节炎症作为丑角鱼鳞病的治疗方法

• 批准号: nhmrc : 1123554
• 负责人: A/Pr Ian Smyth
• 金额: $ 49.05万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulating-inflammation-therapy-harlequin-ichthyosis/947188
• 关键词: Modulating; inflammation; therapy; Harlequin; Ichthyosis

Harlequin Ichthyosis is a severe inherited skin disease caused by mutations in a protein which regulates how skin cells control their levels of lipids. Treatments for this disease are limited and do little to improve patients condition. We believe we have found a new way to treat this condition by altering tissue inflammation. This grant will undertake important experiments aimed at developing new therapies for this currently incurable disease.

丑角鱼鳞病是一种严重的遗传性皮肤病，由调节皮肤细胞如何控制脂质水平的蛋白质突变引起。对这种疾病的治疗是有限的，对改善患者的状况几乎没有帮助。我们相信我们已经找到了一种通过改变组织炎症来治疗这种疾病的新方法。这笔赠款将用于开展旨在为这种目前无法治愈的疾病开发新疗法的重要实验。