Involvement of the Asciz gene in kidney development and disease

Asciz 基因参与肾脏发育和疾病

• 批准号: nhmrc : 1022239
• 负责人: A/Pr Ian Smyth
• 金额: $ 39.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/involvement-asciz-gene-development-disease/110176
• 关键词: Involvement; Asciz; gene; kidney; development

Congenital abnormalities of the kidney and urinary tract (CAKUT) affect more than 1/500 children. Urogenital development is primarily controlled by a small number of genes that regulate the timing and position of kidney formation. In this application we describe a novel gene involved in this process, establish where it acts, how it regulates gene expression and whether mutations in it cause CAKUT.

先天性肾脏和泌尿道异常（CAKUT）影响超过1/500的儿童。泌尿生殖系统的发育主要由少数基因控制，这些基因调节肾脏形成的时间和位置。在本申请中，我们描述了一种参与这一过程的新基因，确定了它在哪里起作用，它如何调节基因表达以及它的突变是否会导致CAKUT。