Applying functional genomics to kidney disease

将功能基因组学应用于肾脏疾病

• 批准号: nhmrc : 1098654
• 负责人: A/Pr Ian Smyth
• 金额: $ 84.57万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/applying-functional-genomics-kidney-disease/662391
• 关键词: Applying; functional; genomics; kidney; disease

In this proposal, we will use genome sequencing to identify novel mutations in patients presenting with kidney disease. We will also generate stem cell lines from these patients and their unaffected relatives in order to model the disease. Finally, we will create animal models of the same mutations. As a result, we hope to better understand the causes of the disease and begin to develop new treatment options.

在这项提案中，我们将使用基因组测序来识别出现肾脏疾病患者的新突变。我们还将从这些患者及其未受影响的亲属那里培养干细胞系，以建立疾病模型。最后，我们将创建相同突变的动物模型。因此，我们希望更好地了解这种疾病的原因，并开始开发新的治疗方案。