Understanding the developmental basis of kidney disease

了解肾脏疾病的发育基础

• 批准号: nhmrc : 1106516
• 负责人: A/Pr Ian Smyth
• 金额: $ 42.93万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-developmental-basis-kidney-disease/662915
• 关键词: Understanding; developmental; basis; kidney; disease

Kidney disease is a considerable burden on the health system and much of it derives from events that occur during organ development. In this grant I will investigate why human nephron number varies between people, how renal cysts form and what genes are mutated in patients with congenital kidney malformations.

肾脏疾病给卫生系统带来了相当大的负担，其中很大一部分是由器官发育过程中发生的事件造成的。在这笔赠款中，我将调查为什么人类肾单位的数量在不同的人之间不同，肾囊是如何形成的，以及先天性肾畸形患者中哪些基因发生了突变。