The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis

ABCA12转运蛋白在表皮脂质稳态和动脉粥样硬化中的作用

• 批准号: nhmrc : 545906
• 负责人: A/Pr Ian Smyth
• 金额: $ 34.43万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-abca12-transporter-homeostasis-atherosclerosis/81923
• 关键词: role; ABCA12; transporter; epidermal; lipid

We have shown that a protein called Abca12 can control the transport of lipids in our bodies. If the function of this gene is attenuated both human and mice develop severe skin disease. Our preliminary results indicate the Abca12 protein regulates cholesterol transport in particular, and this grant will investigate how this might affect normal skin function and contribute to the heart disease atherosclerosis, one of the most common causes of death in the western world.

我们已经证明，一种名为Abca12的蛋白质可以控制我们体内脂质的运输。如果这种基因的功能减弱，人和老鼠都会患上严重的皮肤病。我们的初步结果表明，Abca12蛋白特别调节胆固醇的转运，这项资助将研究这可能如何影响正常的皮肤功能，并导致心脏病动脉粥样硬化，这是西方世界最常见的死亡原因之一。