The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis
The role of the ABCA12 transporter in epidermal lipid homeostasis and atherosclerosis
批准号:
nhmrc : 545906
负责人:
A/Pr Ian Smyth
金额:
$34.43万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
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英文摘要
We have shown that a protein called Abca12 can control the transport of lipids in our bodies. If the function of this gene is attenuated both human and mice develop severe skin disease. Our preliminary results indicate the Abca12 protein regulates cholesterol transport in particular, and this grant will investigate how this might affect normal skin function and contribute to the heart disease atherosclerosis, one of the most common causes of death in the western world.
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海外基金