ABCA12 – a New Regulator of Cellular Lipid Metabolism and Inflammation

ABCA12 — 细胞脂质代谢和炎症的新调节剂

• 批准号: nhmrc : 1020281
• 负责人: A/Pr Ian Smyth
• 金额: $ 52.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/abca12-new-regulator-metabolism-inflammation/110014
• 关键词: ABCA12; New; Regulator; Cellular; Lipid

Dysregulation of cholesterol metabolism plays a key role in a number of diseases – from diabetes and atherosclerosis to neurological and skin disorders. Mechanisms of regulation of cholesterol metabolism are poorly understood. We have recently discovered a new pathway regulating cholesterol metabolism and in this study we will investigate molecular, cellular and physiological mechanisms of this pathway and will identify the possibilities to target it for therapeutic intervention.

胆固醇代谢失调在许多疾病中起着关键作用-从糖尿病和动脉粥样硬化到神经和皮肤疾病。胆固醇代谢的调节机制知之甚少。我们最近发现了一种调节胆固醇代谢的新途径，在这项研究中，我们将研究这种途径的分子，细胞和生理机制，并将确定靶向治疗干预的可能性。