Nedd4-2: a new player in polycystic kidney disease

Nedd4-2：多囊肾病的新参与者

• 批准号: nhmrc : 1099307
• 负责人: A/Pr Ian Smyth
• 金额: $ 46.07万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nedd4-2-new-kidney-disease/662441
• 关键词: Nedd4; new; player; polycystic; kidney

Polycystic kidney disease (PKD) is a life threatening disorder affecting over 12 million people worldwide. This project is based on our discovery of a new gene that controls PKD. Using kidney specific gene knockout, biochemical and cellular approaches we will now address how this gene controls PKD. The results from this study will lead to better understanding of the underlying mechanisms that cause PKD, thus providing possible new targets for therapeutic interventions.

多囊肾病（PKD）是一种危及生命的疾病，影响全球超过1200万人。这个项目是基于我们发现了一个控制PKD的新基因。使用肾脏特异性基因敲除，生物化学和细胞方法，我们现在将解决这个基因如何控制PKD。这项研究的结果将导致更好地了解导致PKD的潜在机制，从而为治疗干预提供可能的新靶点。