Modulation of HIV-1 latency in primary CD4 T cells by chemokines and dendritic cells

趋化因子和树突状细胞对原代 CD4 T 细胞中 HIV-1 潜伏期的调节

• 批准号: nhmrc : 491154
• 负责人: A/Pr Anthony Jaworowski
• 金额: $ 25.35万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-hiv-1-dendritic-cells/78302
• 关键词: Modulation; HIV; latency; primary; CD4

Although treatment of HIV using antiretroviral drugs has dramatically improved outcome the presence of latent infection in long lived T cells has so far prevented cure of HIV infection. This study examines the roles of chemokines (proteins that control cell migration) and a special type of infection fighting cell, the dendritic cell, in generating latent infection in resting T cells. These studies could potentially identify new ways to treat and potentially cure HIV infection.

虽然使用抗逆转录病毒药物治疗艾滋病毒已极大地改善了预后，但长寿T细胞中潜伏感染的存在迄今阻碍了艾滋病毒感染的治愈。这项研究考察了趋化因子(控制细胞迁移的蛋白质)和一种特殊类型的抗感染细胞--树突状细胞--在静息T细胞中产生潜伏感染的作用。这些研究可能会确定治疗和治愈艾滋病毒感染的新方法。