A new monocyte atherogenic phenotype in chronic HIV disease.

慢性艾滋病疾病中一种新的单核细胞致动脉粥样硬化表型。

• 批准号: nhmrc : GNT1108792
• 负责人: A/Pr Anthony Jaworowski
• 金额: $ 63.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-monocyte-atherogenic-hiv-disease/1346659
• 关键词: new; monocyte; atherogenic; phenotype; chronic

Most HIV+ people in Australia now die from cardiovascular disease, caused by atherosclerosis or thickening of coronary arteries. The ability of a white blood cell called the monocyte to prevent atherosclerosis is impaired in HIV. This project aims to understand how HIV does this and how we can reverse the effect. Understanding these processes will also help improve treatments to reduce heart disease in people with other chronic inflammatory conditions.

澳大利亚的大多数艾滋病毒+患者现在死于动脉粥样硬化或冠状动脉增厚引起的心血管疾病。一种称为单核细胞的白色血细胞预防动脉粥样硬化的能力在HIV中受损。该项目旨在了解艾滋病毒是如何做到这一点的，以及我们如何扭转这种影响。了解这些过程也将有助于改善治疗方法，以减少患有其他慢性炎症疾病的人的心脏病。