The role of chemokines in establishing HIV latency

趋化因子在建立 HIV 潜伏期中的作用

• 批准号: nhmrc : 1002761
• 负责人: A/Pr Anthony Jaworowski
• 金额: $ 24.81万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-chemokines-establishing-hiv-latency/108859
• 关键词: role; chemokines; establishing; HIV; latency

Although antiviral therapy is effective in controlling HIV, therapy must be continued life-long because the virus cannot be cleared from long lived infected CD4+ T cells that are silently or latently infected. In this proposal we will explore the mechanism of how HIV can enter these resting CD4+ T-cells and establish long lived latent infection. Understanding this process may potentially lead to new strategies to cure HIV infection.

虽然抗病毒治疗在控制艾滋病毒方面是有效的，但治疗必须持续终生，因为病毒无法从长期存活的感染的CD4+T细胞中清除，这些细胞是静默或潜伏感染的。在这项提案中，我们将探索HIV如何进入这些静止的CD4+T细胞并建立长期潜伏感染的机制。了解这一过程可能会导致治愈艾滋病毒感染的新战略。