Phagocytic clearance and immune activation in malaria

疟疾中的吞噬细胞清除和免疫激活

• 批准号: nhmrc : 628611
• 负责人: A/Pr Anthony Jaworowski
• 金额: $ 37.65万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phagocytic-clearance-immune-activation-malaria/77026
• 关键词: Phagocytic; clearance; immune; activation; malaria

Macrophage white blood cells clear malaria infected cells by eating them, by three routes- by recognising ANTIBODIES or COMPLEMENT on the cell surface, or by the cell BINDING directly to the macrophage. Each has different results, such as amounts of cytokines produced. Cytokines clear malaria; in excess they can cause fatal immune pathology. We will investigate how variations in amount of antibody and complement and route of uptake of malaria infected cells might determine malaria outcome.

巨噬细胞白细胞通过吃掉疟疾感染的细胞来清除它们，通过三种途径——通过识别细胞表面上的抗体或补体，或者通过细胞直接与巨噬细胞结合。每种都有不同的结果，例如产生的细胞因子的量。细胞因子清除疟疾；过量会导致致命的免疫病理。我们将研究抗体和补体数量的变化以及疟疾感染细胞的摄取途径如何决定疟疾的结果。