A longitudinal study of Natural Killer cell function in HIV-infected individuals initiating therapy

开始治疗的 HIV 感染者自然杀伤细胞功能的纵向研究

• 批准号: nhmrc : 1048536
• 负责人: A/Pr Anthony Jaworowski
• 金额: $ 41.35万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/longitudinal-study-natural-initiating-therapy/112021
• 关键词: longitudinal; study; Natural; Killer; cell

HIV infected people no longer die from AIDS but suffer and die from non-AIDS conditions such as non-AIDS related cancers. We have discovered persistent abnormalities in natural killer cells in HIV patients receiving antiretroviral therapy. These cells help prevent the development of and control cancers so understanding why they are abnormal in HIV patients will help prevent early death from non-AIDS cancers.

艾滋病毒感染者不再死于艾滋病，而是死于非艾滋病疾病，如与艾滋病无关的癌症。我们发现，在接受抗逆转录病毒治疗的艾滋病毒患者中，自然杀伤细胞存在持续异常。这些细胞有助于预防和控制癌症的发展，因此了解它们在艾滋病患者中异常的原因将有助于预防非艾滋病癌症的早期死亡。