SAFETY OF GANODERMA LUCIDUM EXTRACT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 灵芝是一种草药，通常用于东方国家作为治疗各种医疗条件的补救措施。 在这项临床研究中，我们测试了16名志愿者口服灵芝的安全性。 人类受试者接受2克草药提取物或安慰剂，每天两次，连续10天。 在研究过程中，从主观问卷中获得的信息表明他们的幸福感，并进行了几个不同的实验室测试。 此外，还进行了反映免疫力或身体对某些疾病的抵抗力的血液检查。 我们的研究结果表明，与安慰剂组相比，草药提取物摄入后没有观察到不良反应。 由于参与本研究的受试者数量相对较少，因此免疫试验结果不具有决定性，因此仍有待于将来重新评价。 我们的研究还表明，需要一个额外的长期安全性临床试验，更高的草药剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ganoderma lucidum is an herbal medicine commonly used in oriental countries as a remedy for treating various medical conditions. In this clinical study, we tested the safety of oral intake of Ganoderma lucidum in 16 human volunteers. The human subjects received 2 grams of the herbal extract or placebo twice daily for 10 consecutive days. During the study, information from subjective questionnaires indicating their well-being were obtained, and several different laboratory tested were performed. In addition, blood tests reflecting immunity or body resistance to certain illness were done. Our study results showed that compared to placebo group, no adverse effects were observed after the herbal extract intake. Due to relatively small number of subject participated in this study, the immunity test results were not conclusive, and thus, remains to be re-evaluated in the future. Our study also suggested that an additional long-term safety clinical trial with higher herbal dose is needed.