TRAINING IN CANCER THERAPEUTICS

描述（由申请人提供）：南卡罗来纳医科大学（MUSC）和罗林斯癌症中心提出了一项关于癌症治疗的跨学科研究培训计划的申请，要求为博士后提供支持。它旨在培养具有生物医学科学背景的有前途的年轻科学家，特别强调癌症管理以及开发针对特定癌症的新疗法所需的实验策略，方法和技术。毫无疑问，在未来的几十年里，我们对参与癌症治疗的分子（化学和生物）的结构和功能的理解将会有更快的进展。这些见解的成功应用将允许开发新的治疗方法来治疗和预防癌症。这种进步需要训练有素、精力充沛、富有成果的科学家，他们有能力在生理背景下理解和操纵分子事件。这些都是我们通过这个培训项目的综合博士后组成部分来培养的个人类型。导师资格的教师是根据他们与癌症治疗相关的研究兴趣，积极的NIH研究支持，正在进行的合作，成功的培训和指导经验，以及对博士后培训的承诺来选择的。其中教授18人，副教授2人，助理教授4人。他们有良好的出版记录和充足的资金。19人（80%）持有NCI研究基金。他们分别来自医学院的生物化学、生物统计学、细胞生物学、医学、微生物学、病理学、药理学、外科学和药学院2个学院的9个系。项目主任和联席主任由一个项目指导委员会和一个由小分子和基因治疗领域杰出专家组成的外部咨询委员会协助。培训计划的关键组成部分是有指导的研究经验，提供癌症广泛视角的必修课，负责任的研究行为的必修课，选修课程，期刊俱乐部，研讨会，在地区和国家会议上的演讲，以及专业发展活动。项目评估是培训项目的一个强项。

DESCRIPTION (provided by applicant): This proposal from the Medical University of South Carolina (MUSC) and the Rollings Cancer Center requests support for an interdisciplinary research training program in cancer therapeutics for postdoctoral fellows. It is designed to train promising young scientists with backgrounds in the biomedical sciences with special emphasis on the management of cancer and the experimental strategies, approaches, and technologies necessary to develop novel therapeutics targeting specific cancers. Future decades will undoubtedly see even more rapid advances in our understanding of the structure and function of molecules (both chemical and biological) involved in cancer therapy. Successful application of these insights will permit development of novel therapeutic approaches to the treatment and prevention of cancer. Such advances will require well-trained, energetic, and productive scientists with the ability to understand and manipulate molecular events within a physiological context. These are the type of individuals we aim to develop through the integrated postdoctoral components of this training program. The Mentor-eligible Faculty Members were selected based on their research interests related to cancer therapeutics, active NIH research support, ongoing collaborations, successful training and mentoring experience, and commitment to postdoctoral training. The 24 members include 18 professors, 2 associate professors, and 4 assistant professors. They have strong publication records and are well funded. Nineteen (80%) hold NCI research grants. They represent 9 departments in 2 colleges (Biochemistry, Biostatistics, Cell Biology, Medicine, Microbiology, Pathology, Pharmacology, and Surgery in the College of Medicine, and Pharmaceutical Sciences in the College of Pharmacy). The Program Director and co-Director are assisted by a Program Steering Committee and an External Advisory Committee of outstanding experts in the field of small molecule and gene therapy. Key components of the training program are the mentored research experience, a required course providing a broad perspective of cancer, required training in responsible conduct of research, elective courses, journal clubs, seminars, presentations at regional and national conferences, and professional development activities. Program evaluation is a strength of the training program.