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A Systems Neuroscience Approach for the Study of General Anesthesia

用于研究全身麻醉的系统神经科学方法

基本信息

批准号：
7666270
负责人：
EMERY N BROWN
金额：
$ 87.5万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7666270
关键词：
Absence of pain sensation Adrenal Glands Adrenergic Receptor Adverse effects Affect Algorithms American Amnesia Amygdaloid structure Anatomy Anesthesia procedures Anesthesiology Anesthetics Animals Anterior Apnea Area Arousal Auditory Autonomic nervous system Award Bees Behavioral Behavioral Paradigm Binding Biological Assay Biological Models Blood Blood Pressure Blood specimen Boston Brain Brain Part Brain Stem Brain region Breathing Cardiovascular system Characteristics Classification Clinical Clinical Medicine Clinical Nursing Research Clinical Services Clonidine Collaborations Coma Communities Complex Conscious Conscious Sedation Corpus striatum structure Coupling Critical Care Cytoskeleton Data Dentistry Development Device Designs Discipline Discipline of obstetrics Dose Drug Combinations Drug Delivery Systems Drug Kinetics Drug effect disorder Electroencephalogram Engineering Environmental air flow Esthesia Europe Failure Fright Functional Imaging Functional Magnetic Resonance Imaging Funding Mechanisms Future Gastroenterology General Anesthesia General Population General anesthetic drugs Goals Guidelines Hand Health Hearing Heart Rate Hibernation Hippocampus (Brain)Human Human Volunteers Hypnosis Hypotension Hypothalamic structure Image Infusion procedures Insula of Reil Interdisciplinary Study International Intervention Intravenous Intubation Isoflurane Knowledge Lead Learning Link Lipid A Macaca Maintenance Malpractice Measurement Measures Medial Mediating Medical Medicine Meditation Memory Methods Microdialysis Microinjections Microtubules Modality Modeling Modern Medicine Molecular Molecular Biology Monitor Monkeys Morbidity - disease rate Motor Cortex Movement Myocardial dysfunction N-Methyl-D-Aspartate Receptors Nature Nausea and Vomiting Neuroanatomy Neurology Neuromuscular Junction Neurons Neurosciences Neurosciences Research Neurosecretory Systems Neurotransmitters Nucleus Accumbens Operative Surgical Procedures Pain Pain Research Parietal Pathway interactions Patients Pattern Pediatrics Perception Peripheral Nerves Pharmaceutical Preparations Pharmacodynamics Physiologic Monitoring Physiological Play Positioning Attribute Postoperative Period Prefrontal Cortex Primates Procedures Process Property Propofol Protein Binding Protocols documentation Psychiatry Psychology Pupil Qualifying Radiology Specialty Rattus Recruitment Activity Reflex action Regulation Reporting Research Research Design Research Ethics Committees Research Personnel Resources Risk Role Safety Saimiri Site Sleep Societies Somatosensory Cortex Source Specialist Spinal Cord Spinal nerve structure Stimulus Students Study Subject Study models System Tactile Techniques Technology Testing Thalamic structure Time Tracheostomy Tube Tracheostomy procedure Training Translating Unconscious State United States United States National Institutes of Health Universities Vegetative States Ventilatory Depression Work World War II abstracting alpha-adrenergic receptor auditory pathway awake basal forebrain base biological adaptation to stress clinical practice computational neuroscience computerized data processing design drug development frontal lobe gamma-Aminobutyric Acid gray matter hemodynamics high risk human subject hypnotic improved innovation insight interest locus ceruleus structure loved ones medical schools meetings monitoring device mortality motor control nanoparticle neural circuit neuroimaging neuromechanism neurophysiology neurosurgery novel novel strategies programs quantum raphe nuclei receptor relating to nervous system research study response somatosensory spinal tract success theories volunteer

项目摘要

General anesthesia is a drug-induced, reversible condition comprised of five behavioral states: hypnosis (loss of consciousness), amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and hemodynamic stability with control of the stress response. The mechanisms by which anesthetic drugs induce the state of general anesthesia remain one of the biggest mysteries of modern medicine. Study of the neural circuitry responsible for each of the five behavioral states of general anesthesia is a fundamental question being investigated in systems neuroscience but not for the purpose of understanding anesthesia. I propose to use systems neuroscience paradigms to establish an interdisciplinary program to solve the mystery of general anesthesia. The program will consist of a set of coordinated studies in humans, monkeys and rats using the same anesthetic agents, in addition to use of dynamical systems modeling studies of anesthetic effects on neural circuits and the development of new signal processing algorithms to track in real-time the dynamics of brain states under general anesthesia. The animal studies will use established behavioral paradigms, fMRI, and multielectrode methods to track brain activity, and microinjection and novel nanoparticle methods for site- specific delivery of anesthetic drugs. The human studies will track brain states under anesthesia using fMRI and simultaneously recorded EEG. The investigators will collaborate to integrate this information across the different systems and scales. This project will lead to a more precise, neurophysiologically-based understanding of general anesthesia, safer protocols for anesthetic drug-development, site-specific methods for anesthetic drug delivery and the design of better, neurophysiologically-based methods for measuring depth of anesthesia. Therefore, this research will improve human health by reducing the risk of anesthesia-related morbidity for patients whose surgical or medical therapies require general anesthesia. This research will also have broad impact on the training of anesthesiologists by placing greater emphasis on systems neuroscience.

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