ANTERIOR PITUITARY HORMONE REPLACEMENT IN TRAUMATIC BRAIN INJURY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 创伤是公认的甲状旁腺功能减退的原因。在患有需要住院和康复的创伤性脑损伤(TBI)的成年人中，有15%到20%的人被生长激素(GH)刺激测试发现患有生长激素(GH)缺乏。此外，皮质醇和甲状腺轴也出现了异常。这项建议的假设是，对于有GH、甲状腺或皮质醇轴异常记录的脑损伤患者，激素替代将改善肌肉功能、身体成分、有氧能力(GH)和神经心理功能(GH、甲状腺、皮质醇)测试的表现。本研究的目的是：1)研究甲状腺激素替代治疗对脑外伤患者神经心理功能的影响；2)研究皮质醇替代治疗对脑外伤患者神经心理功能的影响；3)研究重组人生长激素对脑外伤患者肌肉功能、身体成分、有氧能力和神经心理功能的影响。研究地点将包括加尔维斯顿的UT.M.B.综合临床研究中心、加尔维斯顿的过渡学习中心(TLC)和休斯顿的研究与康复研究所(TIRR)。在加尔维斯顿的GCRC专门进行的活动将包括有氧能力测试、力量测试、身体成分分析和生长激素治疗组的肌肉活组织检查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Trauma is a well-recognized cause of hypopituitarism. Fifteen to twenty percent of adults who suffer a traumatic brain injury (TBI) that requires hospitalization and rehabilitation have been found to have growth hormone (GH) deficiency by GH stimulation testing. Moreover, abnormalities have also been established for the cortisol and thyroid axis. The hypothesis of this proposal is that hormone replacement in TBI patients with documented abnormalities in the GH, thyroid, or cortisol axis will improve muscle function, body composition, aerobic capacity (GH) and performance in tests of neuropsychologic function (GH, thyroid, cortisol). The Aims of this study are to: 1) determine the effect of thyroid hormone replacement on neuropsychologic function in subjects with TBI, 2) determine the effect of cortisol replacement on neuropsychologic function in subjects with TBI, and 3) determine the effect of recombinant human growth hormone (rhGH) on muscle function, body composition, aerobic capacity, and neuropsychologic function in subjects with TBI. Study sites will include, the General Clinical research center at U.T.M.B. in Galveston, the Transitional Learning Center (TLC) in Galveston, and at The Institute for Research and Rehabilitation (TIRR) in Houston. Activities specifically conducted at the GCRC in Galveston will include aerobic capacity testing, strength testing, body composition analysis, and muscle biopsies on the growth hormone treatment group.