Southwest Oncology Group Statistical Center

西南肿瘤学组统计中心

• 批准号: 7383151
• 负责人: JOHN J CROWLEY
• 金额: $ 445.97万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7383151
• 关键词: Cancer Control Research; Clinical Trials; Clinical Trials[{..}] Cancer Control; Community Clinical Oncology Program; Computer software; Computers; Data; Data Storage and Retrieval; Disease; Experimental Designs; Future; Institution; Internet; Late Effects; Literature; Malignant Neoplasms; Minority; Monitor; Nurses; Oncologist; Outcome; Patients; Policies; Prevention; Procedures; Process; Prognostic Factor; Protocols documentation; Publishing; Quality Control; Randomized; Research; Research Design; Research Infrastructure; Research Personnel; Research Subjects; Role; Sample Size; Scientific Advances and Accomplishments; Southwest Oncology Group; Technology; Urologic Cancer; Vertebrates; Woman; Work; anticancer research; data management; design; human subject; improved; member; outreach program; statistical center

DESCRIPTION (provided by applicant): The Southwest Oncology Group is a major multi-disease, multi-disciplinary, multi-institution group engaged in cooperative cancer research. This organization now consists of 35 Member Institutions, 29 Community Clinical Oncology Programs (CCOPs), 230 Affiliates, and 26 Urologic Cancer Outreach Programs (UCOPs), who together accrue 5,000 patients to clinical trials each year. Currently there are 96 studies open for accrual in 14 committees. The Statistical Center is essential to the design, conduct, and analysis of the cancer research in the Southwest Oncology Group. Its main functions are: (1) to participate in the review of proposed protocols, particularly as regards experimental design, sample size, and feasibility; (2) to provide for registration of all patients on all studies, and for randomization where appropriate; (3) to develop Web and software technology for paperless submission of data; (4) to provide for review and quality control of data collected during studies; (5) to provide for data entry and for computer processing and storage and retrieval of data; (6) to work with the Group chair and other investigators in the Group to improve the quality of clinical trials through improved forms, more uniform and reproducible data definitions, and more economical flow of data; (7) to assist the Group chair in the administration of the Group; (8) to analyze and publish the results of studies in conjunction with the study coordinators; (9) to use the data collected to try to find new leads regarding prognostic factors and late effects; (10) to perform statistical research on the efficient design, conduct, and analysis of cancer clinical trials and cancer control research; and (11) to educate investigators, nurse oncologists and CRAs in statistical analysis, research design and the utilization of the most advanced scientific and data management strategies.

描述（申请人提供）：西南肿瘤学组是一个多病种、多学科、多机构从事癌症合作研究的大型团体。该组织目前由 35 个成员机构、29 个社区临床肿瘤学项目 (CCOP)、230 个附属机构和 26 个泌尿科癌症外展项目 (UCOP) 组成，每年总共吸引 5,000 名患者参加临床试验。目前，14 个委员会有 96 项研究可供应计。统计中心对于西南肿瘤学组癌症研究的设计、实施和分析至关重要。其主要职能是：（1）参与拟议方案的审查，特别是实验设计、样本量和可行性方面的审查； (2) 规定所有研究中所有患者的登记，并酌情进行随机化； （三）开发无纸化数据提交的网络和软件技术； (4) 对研究期间收集的数据进行审查和质量控制； (5) 提供数据输入、计算机处理、数据存储和检索； （6）与小组主席和小组内其他研究者合作，通过改进表格、更统一和可重复的数据定义以及更经济的数据流程来提高临床试验的质量； （七）协助集团主席开展集团管理工作； （八）会同研究协调员分析并公布研究结果； (9) 利用收集到的数据尝试寻找有关预后因素和后期影响的新线索； （十）对癌症临床试验和癌症控制研究的有效设计、实施和分析进行统计研究； (11) 对研究者、肿瘤护士和 CRA 进行统计分析、研究设计以及最先进的科学和数据管理策略的利用方面的教育。