Biostatistics Core

生物统计学核心

• 批准号: 8395590
• 负责人: JOHN J CROWLEY
• 金额: $ 18.73万
• 依托单位: SARC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-26 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8395590
• 关键词: Address; Basic Science; Biological Markers; Biostatistics Core; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Collection; Communication; Consultations; Data; Data Analyses; Development; Ensure; Etiology; Experimental Designs; Goals; Histology; Human Resources; K-Series Research Career Programs; Laboratories; Laboratory Animals; Laboratory Study; Manuscripts; Patients; Quality Control; Reporting; Research; Research Design; Research Personnel; Resources; Role; Sample Size; Statistical Methods; Work; Writing; design; meetings; prospective; research study; sarcoma; symposium

The Biostatistics Core provides state-of-the-art statistical support for all SARC SPORE projects and investigators. The overall goal ofthe SARC SPORE is to better understand the etiology of sarcoma and its histologies, and to develop biomarkers and M new treatment options for sarcoma patients. The Biostatistics Core will provide statistical consultation and collaboration on all aspects of design, analysis and interpretation of the clinical trials and laboratory experiments. Core personnel will work closely with project leaders to ensure that the Biostatistics Core provides state-of-the-art statistical support. The primary objectives of the Biostatistics Core are to: 1. Provide study design and review all laboratory, animal, and clinical studies including feasibility assessment, power analysis, and sample size estimation; 2. Collaborate in the project data analysis, interpretation of results, and writing of final study reports and manuscripts; 3. Facilitate prospective collection, entry and quality control of data for the basic science experiments; and collaborate with the clinical trials core to facilitate quality control of clinical data; and 4. Develop and evaluate statistical methods for experimental design and data analysis. To ensure those aims are met, constant, regular communication among core personnel of this Biostatistics Core, SPORE projects and other Cores is needed, Regular weeKly conference calis among project and core leaders will review progress on clinical trials, laboratory studies and data analysis, ensure issues are recognized/addressed, and apprise leaders of developments.

生物统计核心为所有SARC SPORE项目提供最先进的统计支持， investigators. SARC SPORE的总体目标是更好地了解肉瘤及其病因 组织学，并为肉瘤患者开发生物标志物和新的治疗选择。的 生物统计核心将提供统计咨询和合作的设计，分析和 临床试验和实验室实验的解释。核心人员将与项目密切合作 领导人，以确保生物统计核心提供最先进的统计支持。 生物统计核心的主要目标是： 1.提供研究设计并审查所有实验室、动物和临床研究，包括可行性研究 评估、功效分析和样本量估计; 2.在项目数据分析、结果解释和最终研究报告撰写方面进行合作 和手稿; 3.促进基础科学实验数据的前瞻性收集、输入和质量控制; 并与临床试验中心合作，以促进临床数据的质量控制;以及 4.开发和评估实验设计和数据分析的统计方法。 为了确保实现这些目标，该生物统计学核心人员之间应进行持续、定期的沟通 需要核心，SPORE项目和其他核心，定期召开项目和核心会议 领导人将审查临床试验、实验室研究和数据分析的进展，确保问题得到解决。 认可/解决，并向领导人通报事态发展。