INNATE IMMUNE SYSTEM IN SIV INFECTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管在HIV感染者和SIV/恒河猴动物模型中，细胞免疫与病毒控制有关，但我们仍然不能确切地知道是什么允许一些艾滋病毒感染者抵抗感染，艾滋病毒感染者几年内保持无病，或者疫苗介导的疾病保护所需的免疫类型。病原体-宿主相互作用的结果似乎主要取决于最初接触时发生的事件，天然免疫系统产生的信号和细胞因子影响适应性免疫系统的活动。我们的假设是，免疫系统的两个手臂都参与了最初的病毒复制遏制和疫苗保护。我们将展示先天免疫系统和获得性免疫系统在恒河猴慢性感染SIV过程中的作用。这些研究将确定免疫细胞的变化或病毒特异性抗炎细胞因子的产生是否与慢性感染期间的疾病进展有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although cell-mediated immunity is associated with viral control in HIV-infected humans and in the SIV/rhesus macaque animal model, we still do not exactly know what allows some HIV-exposed individuals to resist infection, HIV-infected patients to remain disease free for several years, or the type of immunity needed for vaccine-mediated protection against disease. The outcome of a pathogen-host interaction seems to depend mainly on events that occur at times of the initial contact, and signals and cytokines produced by the innate immune system affect the actions of the adaptive immune system. Our hypothesis is that both arms of the immune system participate in the initial containment of viral replication and in vaccine protection. We will demonstrate the role of the innate and adaptive immune systems during chronic infection with SIV in rhesus macaques. These studies will determine if changes in immune cells, or production of virus-specific anti-inflammatory cytokines are associated with disease progression during chronic infection.