INNATE IMMUNE SYSTEM IN SIV INFECTION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 虽然细胞介导的免疫与HIV感染者和SIV/恒河猴动物模型中的病毒控制有关，但我们仍然不确切地知道是什么让一些HIV暴露个体抵抗感染，HIV感染患者保持数年无病，或者疫苗介导的疾病保护所需的免疫类型。病原体-宿主相互作用的结果似乎主要取决于最初接触时发生的事件，先天免疫系统产生的信号和细胞因子影响适应性免疫系统的作用。我们的假设是，免疫系统的两个分支都参与了病毒复制的初始遏制和疫苗保护。我们将展示恒河猴慢性感染SIV期间先天性和适应性免疫系统的作用。这些研究将确定免疫细胞的变化或病毒特异性抗炎细胞因子的产生是否与慢性感染期间的疾病进展相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although cell-mediated immunity is associated with viral control in HIV-infected humans and in the SIV/rhesus macaque animal model, we still do not exactly know what allows some HIV-exposed individuals to resist infection, HIV-infected patients to remain disease free for several years, or the type of immunity needed for vaccine-mediated protection against disease. The outcome of a pathogen-host interaction seems to depend mainly on events that occur at times of the initial contact, and signals and cytokines produced by the innate immune system affect the actions of the adaptive immune system. Our hypothesis is that both arms of the immune system participate in the initial containment of viral replication and in vaccine protection. We will demonstrate the role of the innate and adaptive immune systems during chronic infection with SIV in rhesus macaques. These studies will determine if changes in immune cells, or production of virus-specific anti-inflammatory cytokines are associated with disease progression during chronic infection.