INNATE IMMUNE SYSTEM IN SIV INFECTION

SIV 感染中的先天免疫系统

• 批准号: 7716164
• 负责人: Luis David Giavedoni
• 金额: $ 0.29万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716164
• 关键词: Affect; Animal Model; Anti-Inflammatory Agents; Anti-inflammatory; Cells; Cellular Immunity; Chronic; Computer Retrieval of Information on Scientific Projects Database; Containment; Cytokine Signaling; Disease; Disease Progression; Event; Funding; Grant; HIV Infections; Human; Immune; Immune system; Immunity; Individual; Infection; Institution; Macaca mulatta; Mediating; Outcome; Patients; Production; Research; Research Personnel; Resources; Role; SIV; Source; Time; United States National Institutes of Health; Upper arm; Vaccines; Viral; Virus; cytokine; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although cell-mediated immunity is associated with viral control in HIV-infected humans and in the SIV/rhesus macaque animal model, we still do not exactly know what allows some HIV-exposed individuals to resist infection, HIV-infected patients to remain disease free for several years, or the type of immunity needed for vaccine-mediated protection against disease. The outcome of a pathogen-host interaction seems to depend mainly on events that occur at times of the initial contact, and signals and cytokines produced by the innate immune system affect the actions of the adaptive immune system. Our hypothesis is that both arms of the immune system participate in the initial containment of viral replication and in vaccine protection. We will demonstrate the role of the innate and adaptive immune systems during chronic infection with SIV in rhesus macaques. These studies will determine if changes in immune cells, or production of virus-specific anti-inflammatory cytokines are associated with disease progression during chronic infection.

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