SIV INFECTION OF BABOON CELLS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 人类免疫缺陷病毒1型(HIV-1)和HIV-2在人类中的感染是黑猩猩(SIVcpz)和黑猩猩(SIVsmm)的猴免疫缺陷病毒(SIV)多次跨物种传播的结果。虽然超过35个非洲非人灵长类(NHP)物种携带着它们独特的SIV毒株，其中许多是由猿猴之间的传播引起的，但这些自然的SIV感染是慢性的和多产的，但与免疫缺陷无关。巴布亚(Papio hamadryas SSP.)是非洲分布最广的NHP物种之一，尽管它们的家园范围与许多感染SIV的NHP物种重叠，但它们似乎并不是自然感染SIV的。尽管血清学证据表明，在极少数野生狒狒中感染了SIV，但从这些动物中分离出一种复制病毒的报告尚未见报道。对SIV感染产生这种明显的天然抵抗力的原因尚不清楚。已经证明，狒狒对实验性的HIV-1感染没有抵抗力，而可能会感染HIV-2和SHIV。此外，在我们的手中，狒狒淋巴细胞支持SIVmac和SIVagm的有效感染，表明细胞内的抗病毒因子，如APOBEC3蛋白、TRIM-5和Tetherin可能不会导致这种耐药性。我们的长期目标是确定导致狒狒对SIV感染产生天然抵抗力的因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The establishment of human immunodeficiency virus type 1 (HIV-1) and HIV-2 infections in humans is the consequence of multiple cross-species transmissions of simian immunodeficiency viruses (SIVs) from chimpanzees (SIVcpz) and sooty mangabeys (SIVsmm), respectively. While over 35 African nonhuman primate (NHP) species carry their unique strain of SIV, many of which resulted from simian-to-simian transmissions, these natural SIV infections are chronic and productive but not associated with immunodeficiency. Baboons (Papio hamadryas ssp.), one of the most widely distributed African NHP species, do not seem to be naturally infected with SIV even though their home-ranges overlap those of many SIV-infected NHP species. Despite serological evidence for SIV infection in very few wild-living baboons, isolation of a replicating virus from these animals has not been reported. The reasons for this apparent natural resistance to SIV infection are not known. Baboons have been shown not to be resistant to experimental infections with HIV-1 and can be infected with HIV-2 and SHIVs. Further, in our hands, baboon lymphocytes support productive infection with SIVmac and SIVagm, indicating that intracellular antiviral factors like APOBEC3 proteins, Trim-5¿, and Tetherin probably do not contribute to this resistance. Our long-term goal is to identify the factors responsible for natural resistance to SIV infection in baboons.