COMPARISON OF LANTUS AND NPH INSULIN IN THE DAWN PHENOMENON

来得时和 NPH 胰岛素在黎明现象中的比较

• 批准号: 7731271
• 负责人: DAVID M NATHAN
• 金额: $ 0.58万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731271
• 关键词: Blood Glucose; Computer Retrieval of Information on Scientific Projects Database; Daily; Development; Funding; Grant; Individual; Infusion procedures; Injection of therapeutic agent; Institution; Insulin; Insulin-Dependent Diabetes Mellitus; Lantus; Long-Acting Insulin; Normal Pressure Hydrocephalus; Pancreas; Physiological; Range; Research; Research Personnel; Resources; Source; Treatment Protocols; United States National Institutes of Health; analog; glargine; glycemic control; non-diabetic; subcutaneous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In type 1 diabetes, the challenge has been to maintain blood glucose as close to the non-diabetic range as possible. Insulin regimens using insulins with varied activity profiles and continuous subcutaneous insulin infusion have been somewhat successful in mimicking normal pancreatic function. Insulin analogues that provide more stable, basal physiologic insulin levels have led to the development of newer multiple daily injection regimens. We will investigate the differential effects of the very long-acting insulin glargine vs NPH on glycemic control during the early AM (dawn phenomenon) in individuals with type 1 diabetes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在1型糖尿病中，挑战是维持尽可能接近非糖尿病范围的血糖。 使用具有不同活性谱和连续皮下胰岛素输注的胰岛素胰岛素方案在模仿正常胰腺功能方面已经有些成功。 提供更稳定的基础生理胰岛素水平的胰岛素类似物导致了较新的多个日常注射方案的发展。 我们将研究在AM早期（黎明现象）中，非常长效的胰岛素与NPH非常长的胰岛素与NPH对血糖控制的差异作用。