TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 今天将评估三种治疗方案的安全性和有效性-二甲双胍单药;二甲双胍加罗格列酮;二甲双胍加生活方式计划，以减轻体重和增加体力活动-根据10-17岁2型糖尿病儿童（Ty 2DM）的血糖控制时间治疗失败。次要目的：比较和评估两组的安全性和成本效益; 2评估个人和家庭行为对治疗反应的影响; 3比较两组对Ty 2 DM病理生理学的影响（β细胞功能、胰岛素抵抗、身体成分、营养、体力活动、有氧健身、心血管危险因素、微血管并发症、生活质量和心理结局）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TODAY will evaluate the safety and efficacy of three treatment regimens -- metformin alone; metformin plus rosiglitazone; and metformin plus a lifestyle program to reduce weight and increase physical activity -- by time to treatment failure based on glycemic control in children age 10-17 with Type 2 diabetes (Ty2DM). Secondary aims: compare and evaluate the arms' safety and cost- effectiveness; evaluate influence of individual and family behaviors on treatment response; and compare the arms' effects on pathophysiology of Ty2DM (beta cell function, insulin resistance, body composition, nutrition, physical activity, aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life and psychological outcomes).