TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)

青少年 2 型糖尿病的治疗方案（当今）

• 批准号: 7607110
• 负责人: DAVID M NATHAN
• 金额: $ 0.58万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607110
• 关键词: Adolescent; Aerobic; Age; Behavior; Beta Cell; Body Composition; Cell physiology; Child; Computer Retrieval of Information on Scientific Projects Database; Diabetic Angiopathies; Family; Functional disorder; Funding; Grant; Individual; Institution; Insulin Resistance; Life Style; Metformin; Non-Insulin-Dependent Diabetes Mellitus; Physical activity; Quality of life; Research; Research Personnel; Resources; Safety; Source; Time; Today; Treatment Failure; Treatment Protocols; United States National Institutes of Health; Upper arm; Weight Gain; base; cardiovascular risk factor; cost effectiveness; fitness; glycemic control; nutrition; programs; psychological outcomes; response; rosiglitazone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TODAY will evaluate the safety and efficacy of three treatment regimens -- metformin alone; metformin plus rosiglitazone; and metformin plus a lifestyle program to reduce weight and increase physical activity -- by time to treatment failure based on glycemic control in children age 10-17 with Type 2 diabetes (Ty2DM). Secondary aims: compare and evaluate the arms' safety and cost- effectiveness; evaluate influence of individual and family behaviors on treatment response; and compare the arms' effects on pathophysiology of Ty2DM (beta cell function, insulin resistance, body composition, nutrition, physical activity, aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life and psychological outcomes).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 《今日》将评估三种治疗方案的安全性和有效性——单独使用二甲双胍；二甲双胍加罗格列酮；二甲双胍加上生活方式计划，以减轻体重和增加体力活动——根据 10-17 岁 2 型糖尿病 (Ty2DM) 儿童的血糖控制，到治疗失败为止。次要目标：比较和评估武器的安全性和成本效益；评估个人和家庭行为对治疗反应的影响；并比较两组对 Ty2DM 病理生理学的影响（β 细胞功能、胰岛素抵抗、身体成分、营养、体力活动、有氧健身、心血管危险因素、微血管并发症、生活质量和心理结果）。