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TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)

TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)
青少年 2 型糖尿病的治疗方案(当今)
批准号:
7607110
负责人:
DAVID M NATHAN
金额:
$0.58万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-12-01 至 2007-11-30

项目摘要

项目成果

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中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金, 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 今天将根据10-17岁2型糖尿病(Ty2 DM)儿童的血糖控制情况,评估三种治疗方案的安全性和有效性--单用二甲双胍;二甲双胍加罗格列酮;以及二甲双胍加生活方式计划,以减轻体重和增加体力活动--根据治疗失败的时间。次要目的:比较和评价ARM的安全性和成本-效果;评估个人和家庭行为对治疗反应的影响;比较ARM对2型糖尿病的病理生理学(β细胞功能、胰岛素抵抗、身体成分、营养、体力活动、有氧健身、心血管危险因素、微血管并发症、生活质量和心理结果)的影响。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TODAY will evaluate the safety and efficacy of three treatment regimens -- metformin alone; metformin plus rosiglitazone; and metformin plus a lifestyle program to reduce weight and increase physical activity -- by time to treatment failure based on glycemic control in children age 10-17 with Type 2 diabetes (Ty2DM). Secondary aims: compare and evaluate the arms' safety and cost- effectiveness; evaluate influence of individual and family behaviors on treatment response; and compare the arms' effects on pathophysiology of Ty2DM (beta cell function, insulin resistance, body composition, nutrition, physical activity, aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life and psychological outcomes).
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会议论文
Glycemic Reduction Approaches for Treating Diabetes: An Effectiveness Study
  • 批准号:
    8113503
  • 项目类别:
  • 资助金额:
    $31.91万
  • 财政年份:
    2010
  • 负责人:
    DAVID M NATHAN
  • 依托单位:
Glycemic Reduction Approaches for Treating Diabetes: An Effectiveness Study
  • 批准号:
    8152144
  • 项目类别:
  • 资助金额:
    $30.9万
  • 财政年份:
    2010
  • 负责人:
    DAVID M NATHAN
  • 依托单位:
LOOK AHEAD: ACTION FOR HEALTH IN DIABETES
  • 批准号:
    7731311
  • 项目类别:
  • 资助金额:
    $0.5万
  • 财政年份:
    2008
  • 负责人:
    DAVID M NATHAN
  • 依托单位:
CLINICAL TRIAL: TODAY
  • 批准号:
    7731247
  • 项目类别:
  • 资助金额:
    $0.28万
  • 财政年份:
    2008
  • 负责人:
    DAVID M NATHAN
  • 依托单位:
海外基金