TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)

青少年 2 型糖尿病的治疗方案（当今）

• 批准号: 7731316
• 负责人: DAVID M NATHAN
• 金额: $ 0.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731316
• 关键词: Adolescent; Aerobic; Age; Behavior; Beta Cell; Body Composition; Cell physiology; Child; Computer Retrieval of Information on Scientific Projects Database; Diabetic Angiopathies; Family; Functional disorder; Funding; Grant; Individual; Institution; Insulin Resistance; Life Style; Metformin; Non-Insulin-Dependent Diabetes Mellitus; Physical activity; Quality of life; Research; Research Personnel; Resources; Safety; Source; Time; Today; Treatment Failure; Treatment Protocols; United States National Institutes of Health; Upper arm; Weight Gain; base; cardiovascular risk factor; cost effectiveness; fitness; glycemic control; nutrition; programs; psychological outcomes; response; rosiglitazone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TODAY will evaluate the safety and efficacy of three treatment regimens -- metformin alone; metformin plus rosiglitazone; and metformin plus a lifestyle program to reduce weight and increase physical activity -- by time to treatment failure based on glycemic control in children age 10-17 with Type 2 diabetes (Ty2DM). Secondary aims: compare and evaluate the arms' safety and cost- effectiveness; evaluate influence of individual and family behaviors on treatment response; and compare the arms' effects on pathophysiology of Ty2DM (beta cell function, insulin resistance, body composition, nutrition, physical activity, aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life and psychological outcomes).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 今天将评估三种治疗方案的安全性和有效性-二甲双胍单药;二甲双胍加罗格列酮;二甲双胍加生活方式计划，以减轻体重和增加体力活动-根据10-17岁2型糖尿病儿童（Ty 2DM）的血糖控制时间治疗失败。次要目的：比较和评估两组的安全性和成本效益; 2评估个人和家庭行为对治疗反应的影响; 3比较两组对Ty 2 DM病理生理学的影响（β细胞功能、胰岛素抵抗、身体成分、营养、体力活动、有氧健身、心血管危险因素、微血管并发症、生活质量和心理结局）。