CLINICAL TRIAL: TODAY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 影响到整个人口的肥胖流行病也未能幸免于儿童和青少年。随着肥胖症患病率的增加，2型糖尿病已开始在儿童和青少年中被认识到。虽然我们在为1型糖尿病儿童和2型糖尿病成人提供护理方面有着长期的经验，但关于为2型糖尿病儿童和青少年提供护理以实现接近正常血糖的方法的信息很少。TODAY研究是一项多中心临床试验，旨在检查治疗儿童和青少年2型糖尿病的几种治疗方案。该研究将招募10-17岁的确诊为2型糖尿病的儿童，并将他们随机分配到二甲双胍加生活方式干预，曲格列酮或安慰剂组，并确定每种药物在维持长期血糖水平方面的相对益处尽可能接近非糖尿病范围。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The epidemic of obesity that has affected the entire population has not spared children and adolescents. In parallel with the increased prevalence in obesity, Type 2 diabetes has begun to be recognized in children and adolescents. Although we have long-experience in providing care for children with type 1 diabetes and adults with type 2 diabetes, there is little information regarding the means of providing care to achieve near-normal glycemia in children and adolescents with type 2 diabetes. The TODAY study is a multicenter clinical trial designed to examine several treatment options for the treatment of type 2 diabetes in children and adolescents. The study will recruit 10-17 year old children with diagnosed type 2 diabetes and randomly assign them to metformin plus a life-style intervention, troglitazone or placebo and determine the relative benefits of each in maintain in g long-term blood sugar levels as close to the non-diabetic range as possible.