CLINICAL TRIAL: TODAY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 影响整个人口的肥胖症流行病也未能幸免于儿童和青少年。随着肥胖率的增加，2型糖尿病已经开始在儿童和青少年中得到承认。虽然我们在为1型糖尿病儿童和成人2型糖尿病提供护理方面有很长的经验，但关于为2型糖尿病儿童和青少年提供接近正常血糖的护理手段的信息很少。今天的研究是一项多中心临床试验，旨在研究儿童和青少年2型糖尿病的几种治疗方案。这项研究将招募10-17岁的确诊为2型糖尿病的儿童，并随机将他们分配到二甲双胍加生活方式干预、曲格列酮或安慰剂，并确定每种药物在保持长期血糖水平尽可能接近非糖尿病范围内的相对益处。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The epidemic of obesity that has affected the entire population has not spared children and adolescents. In parallel with the increased prevalence in obesity, Type 2 diabetes has begun to be recognized in children and adolescents. Although we have long-experience in providing care for children with type 1 diabetes and adults with type 2 diabetes, there is little information regarding the means of providing care to achieve near-normal glycemia in children and adolescents with type 2 diabetes. The TODAY study is a multicenter clinical trial designed to examine several treatment options for the treatment of type 2 diabetes in children and adolescents. The study will recruit 10-17 year old children with diagnosed type 2 diabetes and randomly assign them to metformin plus a life-style intervention, troglitazone or placebo and determine the relative benefits of each in maintain in g long-term blood sugar levels as close to the non-diabetic range as possible.