AN FMRI STUDY OF CYTOKINE-RELATED CHANGES IN NEURAL ACTIVITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标 该项目的总体目标是研究全身炎症对与社会疼痛过程，特定情绪刺激和抑郁症状相关的神经反应的影响。 具体目标1：评估实验诱导的全身性炎症是否会导致更高水平的社交困扰，以应对社交拒绝事件以及随后的抑郁症状。 具体目标#2：评估实验诱导的全身性炎症是否会导致背侧前扣带皮层（dACC）的更大活动，这是一个参与社交疼痛处理的神经区域，以响应社交拒绝事件。 具体目标#3：为了评估是否，对于暴露于内毒素的个体，在社会排斥事件期间更大的dACC活性介导增加的促炎细胞因子活性和更大的抑郁症状之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS The general aim of the proposed project is to investigate the effect of systemic inflammation on neural reactivity related to social pain processes, specific emotional stimuli, and depressive symptoms. Specific Aim #1: To assess whether experimentally induced systemic inflammation leads to higher levels of social distress in response to an episode of social rejection as well as later depressive symptoms. Specific Aim #2: To assess whether experimentally induced systemic inflammation leads to greater activity in the dorsal anterior cingulate cortex (dACC), a neural region involved in social pain processing, in response to an episode of social rejection. Specific Aim #3: To assess whether, for individuals exposed to endotoxin, greater dACC activity during the social rejection episode mediates the relationship between increased proinflammatory cytokine activity and greater depressive symptoms.