Exploring the Neural Mechanisms Underlying the Effects of Generativity on Well-Being

探索生成性对幸福感影响的神经机制

• 批准号: 10629179
• 负责人: Naomi Ilana Eisenberger
• 金额: $ 49.41万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629179
• 关键词: Affect; Aging; Amygdaloid structure; Area; Biological Markers; Biology; Blood; Caring; Control Groups; Dedications; Elderly; Feeling; Gene Expression; Generations; Goals; Health; Health Promotion; Immune; Inflammation; Inflammatory; Intervention; Learning; Link; Literature; Measures; Mediating; Mental Health; Methods; Neurobiology; Participant; Pathway interactions; Patient Self-Report; Perception; Personal Satisfaction; Physical activity; Pilot Projects; Play; Population; Productivity; Psyche structure; Public Health; Publishing; Randomized; Research; Resources; Role; Sampling; Septal Area; System; Testing; Ventral Striatum; Well in self; Writing; caregiving; cost; design; disability risk; expectation; group intervention; human old age (65+); improved; inflammatory marker; innovation; insight; mortality; neural; neurobiological mechanism; neuroimaging; neuromechanism; novel; physical conditioning; post intervention; psychologic; psychological distress; response; social; tool

Project Summary Generativity—defined as concern and care for the well-being of others, especially younger generations—is related to better physical and mental health in older adults. Despite the potential for generativity interventions to serve as an important method for improving health and well-being in this population, this is a highly understudied area of research. Furthermore, neurobiological mechanisms behind the effects of generativity on health and well-being have never been examined. As such, this proposal aims to fill these critical gaps in the literature. The goal of this NIA R01 is to investigate the effect of a writing-based generativity intervention on well-being and inflammation in older adults, as well as to examine underlying neurobiological mechanisms behind improvements. Participants (ntotal=200) will be randomly assigned to a 6- week intervention aimed at increasing perceptions of generativity (vs. a control condition). During pre- and post-intervention sessions, all participants will complete: 1) self-report measures of social, mental, and physical well-being, 2) a blood draw (in order to assess multiple markers of inflammation), and 3) a neuroimaging session (in order to assess the caregiving system as a potential neurobiological mechanism). It is hypothesized that participants in the generativity intervention, compared to those in the control condition, will show: 1) improvements in multiple domains of well-being, 2) improvements in biological markers of inflammation (e.g., decreases in pro-inflammatory gene expression), and 3) activation of the neural caregiving system (i.e., increases in neural activity in caregiving-related regions and decreases in threat-related neural activity). Furthermore, it is hypothesized that activation of the neural caregiving system will mediate observed self- reported improvements in social, mental, and physical well-being, as well as inflammatory activity. This study will fill a crucial gap in our understanding of the effect of generativity on well-being and inflammation, as well as the underlying neurobiology of these effects. Finally, these results may ultimately have large-scale public health implications, as they could inform a low-cost, low-effort method for improving health and well-being in older adults.

项目摘要 生成性-定义为关心和关心他人的福祉，特别是年轻人的福祉 几代人--与老年人的身心健康有关。尽管存在潜在的 生成性干预是改善这一地区健康和福祉的重要方法 人口，这是一个研究严重不足的领域。此外，背后的神经生物学机制 生殖能力对健康和幸福的影响从未被研究过。因此，这项提议旨在 填补文献中的这些关键空白。此NIA R01的目标是调查基于书写的 对老年人幸福感和炎症的生殖力干预，以及检查潜在的 改进背后的神经生物学机制。参与者(总数=200人)将被随机分配到6- 周干预的目的是增加人们对生殖能力的感知(与对照条件相比)。在预售期间和 干预后，所有参与者将完成：1)社会、心理和身体方面的自我报告 幸福感，2)抽血(以评估多种炎症标志物)，3)神经成像 会议(目的是评估照料系统作为一种潜在的神经生物学机制)。这是假设的 生成性干预的参与者与控制条件下的参与者相比，将显示：1) 在多个幸福感领域的改善，2)炎症生物标志物的改善(例如， 促炎基因表达的减少)，以及3)神经护理系统的激活(即， 照料相关区域的神经活动增加，威胁相关的神经活动减少)。 此外，还假设神经照顾系统的激活将调节观察到的自我 据报道，在社会、精神和身体健康以及炎症活动方面有所改善。本研究 将填补我们对生殖对幸福感和炎症的影响的理解的一个关键空白，以及 这些效应的潜在神经生物学。最后，这些结果可能最终会有大规模的公众 对健康的影响，因为他们可以提供一种低成本、低成本的方法来改善健康和福祉 上了年纪的人。