Exploring the Neural Mechanisms Underlying the Effects of Generativity on Well-Being

探索生成性对幸福感影响的神经机制

• 批准号: 10629179
• 负责人: Naomi Ilana Eisenberger
• 金额: $ 49.41万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629179
• 关键词: Affect; Aging; Amygdaloid structure; Area; Biological Markers; Biology; Blood; Caring; Control Groups; Dedications; Elderly; Feeling; Gene Expression; Generations; Goals; Health; Health Promotion; Immune; Inflammation; Inflammatory; Intervention; Learning; Link; Literature; Measures; Mediating; Mental Health; Methods; Neurobiology; Participant; Pathway interactions; Patient Self-Report; Perception; Personal Satisfaction; Physical activity; Pilot Projects; Play; Population; Productivity; Psyche structure; Public Health; Publishing; Randomized; Research; Resources; Role; Sampling; Septal Area; System; Testing; Ventral Striatum; Well in self; Writing; caregiving; cost; design; disability risk; expectation; group intervention; human old age (65+); improved; inflammatory marker; innovation; insight; mortality; neural; neurobiological mechanism; neuroimaging; neuromechanism; novel; physical conditioning; post intervention; psychologic; psychological distress; response; social; tool

Project Summary Generativity—defined as concern and care for the well-being of others, especially younger generations—is related to better physical and mental health in older adults. Despite the potential for generativity interventions to serve as an important method for improving health and well-being in this population, this is a highly understudied area of research. Furthermore, neurobiological mechanisms behind the effects of generativity on health and well-being have never been examined. As such, this proposal aims to fill these critical gaps in the literature. The goal of this NIA R01 is to investigate the effect of a writing-based generativity intervention on well-being and inflammation in older adults, as well as to examine underlying neurobiological mechanisms behind improvements. Participants (ntotal=200) will be randomly assigned to a 6- week intervention aimed at increasing perceptions of generativity (vs. a control condition). During pre- and post-intervention sessions, all participants will complete: 1) self-report measures of social, mental, and physical well-being, 2) a blood draw (in order to assess multiple markers of inflammation), and 3) a neuroimaging session (in order to assess the caregiving system as a potential neurobiological mechanism). It is hypothesized that participants in the generativity intervention, compared to those in the control condition, will show: 1) improvements in multiple domains of well-being, 2) improvements in biological markers of inflammation (e.g., decreases in pro-inflammatory gene expression), and 3) activation of the neural caregiving system (i.e., increases in neural activity in caregiving-related regions and decreases in threat-related neural activity). Furthermore, it is hypothesized that activation of the neural caregiving system will mediate observed self- reported improvements in social, mental, and physical well-being, as well as inflammatory activity. This study will fill a crucial gap in our understanding of the effect of generativity on well-being and inflammation, as well as the underlying neurobiology of these effects. Finally, these results may ultimately have large-scale public health implications, as they could inform a low-cost, low-effort method for improving health and well-being in older adults.

项目摘要 生成性 - 定义为关注和关心他人的福祉，尤其是年轻人 几代人 - 与老年人的身体和心理健康相关。尽管有可能 生成性干预措施是改善健康和福祉的重要方法 人口，这是一个备受了解的研究领域。此外，背后的神经生物学机制 从未研究过生成性对健康和福祉的影响。因此，该建议旨在 在文献中填补这些关键空白。该NIA R01的目的是研究基于写作的效果 老年人对幸福感和炎症的生成性干预以及检查的基础 改善背后的神经生物学机制。参与者（ntotal = 200）将随机分配给6-- 一周的干预旨在增加发电的看法（与控制条件）。在前和 干预后会议，所有参与者将完成：1）社会，心理和身体的自我报告措施 幸福感，2）抽血（为了评估多个炎症标记）和3）神经影像学 会议（为了评估护理系统作为潜在的神经生物学机制）。它是假设的 与对照条件下的那些人相比，生成干预的参与者将显示：1） 福祉多个领域的改善，2）炎症生物学标志物的改善（例如， 促炎基因表达的降低）和3）神经护理系统的激活（即 与护理相关区域中神经活动的增加，并减少与威胁相关的神经元活动）。 此外，假设神经护理系统的激活将介导观察到的自我 报道了社会，精神和身体健康以及炎症活动的改善。这项研究 我们将填补我们对产生对幸福感和炎症的影响的关键空白，以及 这些作用的基本神经生物学。最后，这些结果最终可能有大规模的公众 健康的影响，因为他们可以为改善健康和福祉的低成本，低劳动方法提供信息 老年人。