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Exploring the Neural Mechanisms Underlying the Effects of Generativity on Well-Being

探索生成性对幸福感影响的神经机制

基本信息

批准号：
10367818
负责人：
Naomi Ilana Eisenberger
金额：
$ 50.47万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10367818
关键词：
Affect Aging Amygdaloid structure Area Biological Markers Biology Blood Caring Control Groups Elderly Feeling Gene Expression Generations Goals Health Health Promotion Immune Inflammation Inflammatory Intervention Learning Link Literature Measures Mediating Mental Health Methods Neurobiology Participant Pathway interactions Patient Self-Report Perception Personal Satisfaction Physical activity Pilot Projects Play Population Psyche structure Public Health Publishing Randomized Research Resources Role Sampling Septal Area System Testing Ventral Striatum Well in self Writing base caregiving cost design disability risk expectation group intervention human old age (65+)improved inflammatory marker innovation insight mortality neurobiological mechanism neuroimaging neuromechanism novel physical conditioning post intervention psychologic psychological distress relating to nervous system response social tool

项目摘要

Project Summary Generativity—defined as concern and care for the well-being of others, especially younger generations—is related to better physical and mental health in older adults. Despite the potential for generativity interventions to serve as an important method for improving health and well-being in this population, this is a highly understudied area of research. Furthermore, neurobiological mechanisms behind the effects of generativity on health and well-being have never been examined. As such, this proposal aims to fill these critical gaps in the literature. The goal of this NIA R01 is to investigate the effect of a writing-based generativity intervention on well-being and inflammation in older adults, as well as to examine underlying neurobiological mechanisms behind improvements. Participants (ntotal=200) will be randomly assigned to a 6- week intervention aimed at increasing perceptions of generativity (vs. a control condition). During pre- and post-intervention sessions, all participants will complete: 1) self-report measures of social, mental, and physical well-being, 2) a blood draw (in order to assess multiple markers of inflammation), and 3) a neuroimaging session (in order to assess the caregiving system as a potential neurobiological mechanism). It is hypothesized that participants in the generativity intervention, compared to those in the control condition, will show: 1) improvements in multiple domains of well-being, 2) improvements in biological markers of inflammation (e.g., decreases in pro-inflammatory gene expression), and 3) activation of the neural caregiving system (i.e., increases in neural activity in caregiving-related regions and decreases in threat-related neural activity). Furthermore, it is hypothesized that activation of the neural caregiving system will mediate observed self- reported improvements in social, mental, and physical well-being, as well as inflammatory activity. This study will fill a crucial gap in our understanding of the effect of generativity on well-being and inflammation, as well as the underlying neurobiology of these effects. Finally, these results may ultimately have large-scale public health implications, as they could inform a low-cost, low-effort method for improving health and well-being in older adults.

项目总结