Social Facilitation of Emotion Regulation in Adolescence

青春期情绪调节的社会促进

• 批准号: 10588378
• 负责人: Naomi Ilana Eisenberger
• 金额: $ 23.55万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-12 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588378
• 关键词: Adolescence; Adolescent; Adult; Age; Amygdaloid structure; Behavior; Behavioral; Brain; Brain region; Buffers; Cognitive; Collection; Cues; Data; Decision Making; Development; Down-Regulation; Emotional; Emotions; Event; Frequencies; Friends; Functional Magnetic Resonance Imaging; Goals; Intervention; Lateral; Link; National Institute of Child Health and Human Development; Pathway interactions; Patient Self-Report; Play; Prefrontal Cortex; Regulation; Research; Rewards; Risk Behaviors; Role; Shapes; Social Environment; Social Facilitation; Source; Stimulus; Symptoms; Testing; Time; Ventral Striatum; Well in self; Work; adolescent brain development; adolescent health; age group; age related; cognitive control; cognitive reappraisal; efficacy evaluation; emotion dysregulation; emotion regulation; experience; improved; negative affect; neural; neurodevelopment; neuromechanism; novel; peer; peer influence; recruit; reward circuitry; scaffold; showing emotion; social; social interventions; success; therapy design; vulnerable adolescent

Project Summary Adolescents demonstrate a high need for emotion regulation [2-4], but often struggle to employ gold- standard regulatory strategies such as cognitive reappraisal due to underdeveloped lateral prefrontal neuroarchitecture (i.e. lateral prefrontal cortex (LPFC)), which plays a crucial role in cognitive control [5-8]. At the same time, adolescents are exquisitely sensitive to their peers [11,13-16]. Notably, neural regions linked to peer influence in adolescence, including ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC), mature prior to LPFC. Thus, adolescents are uniquely poised to benefit from a social intervention designed to appropriate peer influence mechanisms towards enhancing emotion regulation efficacy. The goal of this R21 is to work with the developing brain, not against it, to utilize adolescent-emergent reward-related circuitry (VS, VMPFC) instead of LPFC to regulate emotion in adolescents. We will administer a novel paradigm during functional magnetic resonance imaging (fMRI) to examine whether adolescents (N = 50) and adults (N = 50) are more effective at down-regulating negative affect when a friend provides them with reinterpretations of negative stimuli (i.e. social reappraisal), as compared to when they reinterpret stimuli alone (i.e., cognitive reappraisal) [12]. Specifically, we will investigate whether social reappraisal is more effective and longer-lasting than cognitive reappraisal in down-regulating negative affect in adolescents and adults (Aim 1). We hypothesize that social reappraisal will be more effective and enduring than cognitive reappraisal in both groups, but that this effect will be larger in adolescents given their heightened sensitivity to peers. Furthermore, we will identify the neural mechanisms supporting social versus cognitive reappraisal and characterize age-related differences in these mechanisms (Aim 2). We will focus on examining activation in the amygdala, LPFC, VS, and VMPFC, as well as functional connectivity between these regions. We hypothesize that LPFC-amygdala connectivity will support cognitive reappraisal, which will be stronger in adults versus adolescents, whereas VS-amygdala and VMPFC-amygdala connectivity will support social reappraisal. While VS-amygdala connectivity is likely to be stronger in adolescents than adults, VMPFC- amygdala connectivity might not be given that this pathway is still developing during adolescence [21,76]. We expect that social reappraisal will have a more transformative and thus longer-lasting effect on amygdala- based representations of negative stimuli, particularly in adolescents, and will use representation similarity analysis to test this hypothesis. Examining the efficacy and neural underpinnings of social reappraisal in adolescents versus adults is an important step in advancing our understanding of how social contexts shape emotion regulation neurodevelopment, with the aim of improving adolescent health and laying the groundwork for positive emotional wellbeing into adulthood.

项目摘要 青少年表现出对情绪调节的高度需求[2-4]，但往往难以使用黄金- 标准的调节策略，如认知重新评估，由于发育不全的外侧前额叶 神经结构（即外侧前额叶皮层（LPFC）），在认知控制中起着至关重要的作用[5-8]。在 与此同时，青少年对他们的同龄人非常敏感[11，13 -16]。值得注意的是， 青少年时期的同伴影响，包括腹侧纹状体（VS）和腹内侧前额叶皮层（vmPFC）， 在LPFC之前成熟。因此，青少年特别容易受益于社会干预， 适当的同伴影响机制有助于提高情绪调节效能。R21的目标是 是与发育中的大脑合作，而不是反对它， 在青少年中，用VS、VMPFC代替LPFC来调节情绪。我们将管理一本小说 在功能性磁共振成像（fMRI）过程中检查青少年（N = 50）和 成年人（N = 50）更有效地下调负面影响时，朋友为他们提供 ·对负面刺激的重新解释（即社会重新评价），与他们单独重新解释刺激时相比 (i.e.,认知再评价）[12]。具体来说，我们将调查社会重新评价是否更有效 在下调青少年和成人的负面影响方面，比认知重新评估更持久（Aim 1）。我们假设，社会重新评价将比认知重新评价更有效和持久， 这两个群体，但这种影响将在青少年中更大，因为他们对同龄人的敏感性更高。 此外，我们将确定支持社会与认知重新评价的神经机制， 描述这些机制中与年龄相关的差异（目的2）。我们将重点研究 杏仁核、LPFC、VS和VMPFC，以及这些区域之间的功能连接。我们 假设LPFC-杏仁核连接将支持认知重新评价，这将是更强的， 成年人与青少年相比，而VS-杏仁核和VMPFC-杏仁核连接将支持社会 重新评估虽然青少年的VS-杏仁核连接可能比成年人更强，但VMPFC- 杏仁核的连接可能不会考虑到这一途径仍在发展中的青春期[21，76]。我们 预期社会重新评价会对杏仁核产生更大的变革性影响，从而产生更持久的影响- 基于消极刺激的表征，特别是在青少年中，并将使用表征相似性 分析来验证这个假设。检查社会重新评价的功效和神经基础， 青少年与成年人的对比是我们理解社会环境如何塑造 情绪调节神经发育，目的是改善青少年健康， 为成年后的积极情绪健康提供帮助。