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Can social support figures enhance fear extinction in patients with social anxiety?

社会支持数字能否增强社交焦虑患者的恐惧消除？

基本信息

批准号：
10308692
负责人：
Naomi Ilana Eisenberger
金额：
$ 19.5万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10308692
关键词：
Adult Affect Anxiety Anxiety Disorders Attenuated Behavior Caring Clinical Cues Development Diagnosis Disease Dropout Extinction (Psychology)Female Fright Future Generalized Anxiety Disorder Health Human Image Impairment Individual Intervention Investigation Learning Life Light Literature Mental Health Methods Neurobiology Opioid Outcome Participant Patient Dropouts Patients Personal Satisfaction Phobias Play Population Post-Traumatic Stress Disorders Prevention strategy Preventive measure Procedures Process Protocols documentation Recording of previous events Relapse Research Resources Risk Role Route Safety Sampling Security Shock Signal Transduction Smiling Social Anxiety Disorder Social support Suggestion Support System System Testing Therapeutic procedure Translating Work anxious base conditioned fear design experience generalized anxiety improved improved outcome neurobiological mechanism neuromechanism novel prevent response social anxiety social attachment successful intervention therapy design therapy outcome tool

项目摘要

Project Summary/Abstract It is estimated that roughly one third of adults in the US will be affected by a fear-related disorder over the course of their lifetime. These disorders, including diagnoses such as generalized anxiety disorder, social anxiety disorder, or post-traumatic stress disorder, are marked by disruptive fears that can interfere with daily life and have harmful long-term consequences on health and well-being. Yet, even the most successful treatment to date, exposure therapy (a set of procedures that employs fear extinction processes to reduce fear) has limited effects, with discomfort during therapy leading to drop-out and relapse remaining a common occurrence. Thus, investigation of methods to augment exposure therapy treatments and improve fear reduction strategies is critical for improving the well-being of individuals with fear-related disorders. Recent work has revealed that social support may represent one such method, demonstrating that social support reminders enhance the extinction of fear and reduce the acquisition of fear in healthy adults. These findings are unexpected, as they are in direct contrast with current views that all safety signals, including social support figures, are harmful during fear-reduction interventions. Thus, while current views would suggest that these cues reduce extinction and enhance acquisition, social support reminders in fact enhance extinction and reduce acquisition. This divergence may be explained by the crucial role of social support in human survival; specifically, the neurobiological mechanisms that have evolved to reinforce social bonds appear to overlap with the systems that support fear learning, making social support uniquely poised to reduce fear. These previous findings hint at the exciting possibility that social support may play an important role in improving outcomes for individuals with fear-related disorders. In particular, the presence of social support reminders (e.g., pictures) may augment exposure therapy treatments, enhancing extinction outcomes, and enrich strategies to prevent fear acquisition in individuals at risk for developing disruptive fears. However, while the fear-reducing effects of social support have been demonstrated in healthy adults, these effects have never been tested in adults with fear-related disorders. Thus, the proposed studies will be the first to explore whether social support 1) enhances fear extinction and 2) reduces fear acquisition in adults with social anxiety disorder (SAD) and healthy controls. In the first study, we will test whether the presence of a social support image (vs. smiling stranger image) leads to enhanced extinction in participants diagnosed with SAD (n=60, 30 females) and healthy controls (n=60, 30 females). In the second study, we will test whether the presence of a social support image (vs. smiling stranger image) reduces acquisition in participants with SAD (n=60, 30 females) and healthy controls (n=60, 30 females). This work will establish whether the fear-reducing effects of social support extend beyond healthy adults to those with fear-related disorders, potentially shedding light on simple, inexpensive ways to augment current fear reduction treatments and attenuate the formation of new fears.

项目总结/文摘