NO DETECTION OF EXERCISE ENERGY EXPENDITURE

无法检测运动能量消耗

基本信息

批准号：
7603784
负责人：
KATARINA T BORER
金额：
$ 0.95万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-01 至 2007-09-16
项目状态：
已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research study is to gain a better understanding of how calories expended during exercise or caloric restriction affect our appetite and food consumption. Rapid growth in the incidence of obesity in the United States and other developed countries has increased the need for a more efficient use of exercise and diet in efforts to prevent or reverse obesity.In this study we will try to answer two questions: (1) Do calories that are eaten have the same effect on our sense of hunger and satiety as the same number of calories delivered directly into the blood? To answer this question, we will compare appetite and satiety produced by food eaten during a meal to the same number of calories introduced by intravenous injection. Our guess is that only calories that we ingest by mouth and digest through our gastro-intestinal tract will affect our sense of hunger and satiety. (2) Do calories that are expended during exercise have the same effect on our sense of hunger and satiety as the same number of calories withheld from a meal? To answer this question, we will compare appetite and satiety resulting from two hours of exercise to the same number of calories withheld from a meal. Our guess is that calories that are expended during exercise do not affect our sense of hunger and satiety, but that the calories withheld from a meal, do. Besides measuring the levels of hunger, desire to eat, the estimate of capacity to eat, and the sense of fullness, we will measure several hormones in the blood samples that will be withdrawn approximately every 30 minutes during 12 hours of daytime. Some of these hormones are thought to signal hunger and satiety, and others are released when our body detects reduced availability of energy. We also will measure energy metabolism by sampling consumption of oxygen and production of waste gas, carbon dioxide. A better understanding of how calories expended during exercise or caloric restriction affect our appetite, and food consumption affects our satiety, will help us develop better strategies for using exercise and food restriction to prevent obesity or induce weight loss.'

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。这项研究的目的是更好地了解运动或热量限制期间的卡路里如何影响我们的食欲和食物。美国和其他发达国家肥胖发生率的迅速增长增加了需要更有效地利用运动和饮食来预防或逆转肥胖症。在这项研究中，我们将尝试回答两个问题：（1）食用的卡路里对我们的饥饿感和饱腹感具有相同的饥饿感，因为直接传递了同样的血液中的同样数量的血液？为了回答这个问题，我们将比较食物中食用的食欲和饱腹感与静脉注射引入的相同卡路里数量。我们的猜测是，只有我们通过胃肠道摄入并消化的卡路里会影响我们的饥饿感和饱腹感。（2）在运动过程中消耗的卡路里是否对我们的饥饿感和饱腹感具有相同的影响，而饮食中的卡路里数量相同？为了回答这个问题，我们将比较两个小时的锻炼的食欲和饱腹感与一顿饭中扣留的卡路里数量相同。我们的猜测是，在运动过程中消耗的卡路里不会影响我们的饥饿感和饱腹感，而是一顿饭中含有的卡路里。除了测量饥饿水平，饮食渴望，食用能力的估计以及丰满感外，我们还将在白天12小时内每30分钟撤回每30分钟的血液样本中的几种激素。这些激素中的一些被认为是饥饿和饱腹感的信号，而当我们的身体发现能量的可用性降低时，则释放了一些激素。我们还将通过采样氧和产生废气，二氧化碳来测量能量代谢。更好地理解运动或热量限制期间的卡路里如何影响我们的食欲，而食物消费会影响我们的饱腹感，将有助于我们制定更好的策略，以防止锻炼和食物限制以防止肥胖或诱发体重减轻。