EXERCISE FOR APPETITE SUPPRESSION & WEIGHT LOSS IN POSTMENOPAUSAL WOMEN

抑制食欲的运动

• 批准号: 7376535
• 负责人: KATARINA T BORER
• 金额: $ 5.72万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376535
• 关键词: appetite; exercise; satiations; suppression; weight loss

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Exercise is often recommended as a means of weight loss with the expectation that it will cause energy expenditure unaccompanied by increased appetite, or that it will suppress appetite. The effects of exercise on appetite are inconsistent and appear to be inhibitory at higher exercise intensities. No increase in food intake after exercise is seen in obese individuals, while increased food intake follows exercise in lean individuals. Several hormones secreted by the gastrointestinal tract appear to control appetite (ghrelin) and satiety (CCK, PYY), as do hormones secreted by other endocrine glands (epinephrine, norepinephrine, insulin) and the adipose tissue (leptin). Almost nothing is known about the role of these hormones in appetite and satiation after exercise. The purpose of this study is to measure plasma concentration of these hormones after exercise in a group of ten lean and another group of ten obese postmenopausal women. The aerobic fitness of women will be tested with a treadmill walking test to establish a moderate (MODEX) walking speed as 40% of their maximal effort, and a fast speed (HIEX) as 80% of maximal effort. All women will be asked to rate their appetite and hunger and will have their hormones measured in blood samples collected at intervals ranging from 15 minutes to one hour, on three occasions separated by at least seven days: a day with no exercise, and during days of MODEX and HIEX. This study will add to our understanding of the effectiveness of exercise to influence hormones that mediate appetite and satiety.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。运动通常被推荐作为减肥的一种手段，人们期望运动会导致能量消耗但不会增加食欲，或者会抑制食欲。运动对食欲的影响不一致，并且在较高运动强度下似乎具有抑制作用。肥胖个体运动后食物摄入量没有增加，而瘦人运动后食物摄入量增加。胃肠道分泌的几种激素似乎可以控制食欲（生长素释放肽）和饱腹感（CCK、PYY），其他内分泌腺（肾上腺素、去甲肾上腺素、胰岛素）和脂肪组织（瘦素）分泌的激素也是如此。关于这些激素在运动后食欲和饱腹感中的作用几乎一无所知。本研究的目的是测量一组 10 名瘦身女性和另一组 10 名肥胖绝经后女性运动后这些激素的血浆浓度。女性的有氧健康将通过跑步机步行测试进行测试，以确定中等（MODEX）步行速度为最大努力的40％，快速步行（HIEX）为最大努力的80％。所有女性都将被要求评估她们的食欲和饥饿感，并在间隔至少 7 天的三种情况下，每隔 15 分钟到 1 小时采集一次血液样本，测量她们的激素水平：没有运动的一天，以及 MODEX 和 HIEX 期间。这项研究将加深我们对运动影响调节食欲和饱腹感的激素的有效性的理解。