EXERCISE FOR APPETITE SUPPRESSION & WEIGHT LOSS IN POSTMENOPAUSAL WOMEN

抑制食欲的运动

• 批准号: 7376535
• 负责人: KATARINA T BORER
• 金额: $ 5.72万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376535
• 关键词: appetite; exercise; satiations; suppression; weight loss

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Exercise is often recommended as a means of weight loss with the expectation that it will cause energy expenditure unaccompanied by increased appetite, or that it will suppress appetite. The effects of exercise on appetite are inconsistent and appear to be inhibitory at higher exercise intensities. No increase in food intake after exercise is seen in obese individuals, while increased food intake follows exercise in lean individuals. Several hormones secreted by the gastrointestinal tract appear to control appetite (ghrelin) and satiety (CCK, PYY), as do hormones secreted by other endocrine glands (epinephrine, norepinephrine, insulin) and the adipose tissue (leptin). Almost nothing is known about the role of these hormones in appetite and satiation after exercise. The purpose of this study is to measure plasma concentration of these hormones after exercise in a group of ten lean and another group of ten obese postmenopausal women. The aerobic fitness of women will be tested with a treadmill walking test to establish a moderate (MODEX) walking speed as 40% of their maximal effort, and a fast speed (HIEX) as 80% of maximal effort. All women will be asked to rate their appetite and hunger and will have their hormones measured in blood samples collected at intervals ranging from 15 minutes to one hour, on three occasions separated by at least seven days: a day with no exercise, and during days of MODEX and HIEX. This study will add to our understanding of the effectiveness of exercise to influence hormones that mediate appetite and satiety.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。通常建议锻炼作为减肥手段，预计会导致食欲增加或会抑制食欲的能量支出。运动对食欲的影响不一致，并且在较高的运动强度下似乎是抑制性的。在肥胖的个体中，肥胖者的摄入量增加后，运动摄入后没有增加食物摄入量的增加。胃肠道分泌的几种激素似乎控制着食欲（Ghrelin）和饱腹感（CCK，PYY），其他内分泌腺体（肾上腺素，去甲肾上腺素，胰岛素）和脂肪组织（leptin）分泌的激素也是如此。这些激素在运动后的食欲和饱腹感中的作用几乎一无所知。这项研究的目的是在运动后在十个瘦肉和十个肥胖的绝经后妇女中测量这些激素的血浆浓度。妇女的有氧运动能力将通过跑步机步行测试进行测试，以确立适中（Modex）的步行速度，这是其最大努力的40％，快速速度（HIEX）是最大努力的80％。将要求所有妇女对食欲和饥饿进行评分，并将其激素以从15分钟到一小时的间隔收集的血液样本中测量，三次至少7天分开：一天没有运动，以及在Modex和Hiex的日子里。这项研究将增加我们对锻炼有效性影响促进食欲和饱腹感的荷尔蒙的有效性的理解。