EXERCISE FOR APPETITE SUPPRESSION & WEIGHT LOSS IN POSTMENOPAUSAL WOMEN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。运动通常被推荐为减肥的一种手段，期望它会导致能量消耗而不伴有食欲增加，或者它会抑制食欲。运动对食欲的影响是不一致的，在较高的运动强度下似乎是抑制的。肥胖的人运动后食物摄入量没有增加，而瘦弱的人运动后食物摄入量增加。胃肠道分泌的几种激素似乎控制食欲（胃饥饿素）和饱腹感（CCK， PYY），其他内分泌腺分泌的激素（肾上腺素，去甲肾上腺素，胰岛素）和脂肪组织（瘦素）也是如此。关于这些激素在运动后食欲和饱腹感中的作用，我们几乎一无所知。这项研究的目的是测量一组10名纤瘦和另一组10名肥胖的绝经后妇女运动后这些激素的血浆浓度。女性将通过跑步机步行测试来测试有氧适能，以确定中等（MODEX）步行速度为最大努力的40%，快速（HIEX）步行速度为最大努力的80%。所有女性将被要求评估她们的食欲和饥饿感，并在血样中测量她们的激素水平，血样采集的时间间隔从15分钟到1小时不等，分三次采集，间隔至少7天：一天不运动，一天服用MODEX和HIEX。这项研究将增加我们对运动影响调节食欲和饱腹感的激素的有效性的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Exercise is often recommended as a means of weight loss with the expectation that it will cause energy expenditure unaccompanied by increased appetite, or that it will suppress appetite. The effects of exercise on appetite are inconsistent and appear to be inhibitory at higher exercise intensities. No increase in food intake after exercise is seen in obese individuals, while increased food intake follows exercise in lean individuals. Several hormones secreted by the gastrointestinal tract appear to control appetite (ghrelin) and satiety (CCK, PYY), as do hormones secreted by other endocrine glands (epinephrine, norepinephrine, insulin) and the adipose tissue (leptin). Almost nothing is known about the role of these hormones in appetite and satiation after exercise. The purpose of this study is to measure plasma concentration of these hormones after exercise in a group of ten lean and another group of ten obese postmenopausal women. The aerobic fitness of women will be tested with a treadmill walking test to establish a moderate (MODEX) walking speed as 40% of their maximal effort, and a fast speed (HIEX) as 80% of maximal effort. All women will be asked to rate their appetite and hunger and will have their hormones measured in blood samples collected at intervals ranging from 15 minutes to one hour, on three occasions separated by at least seven days: a day with no exercise, and during days of MODEX and HIEX. This study will add to our understanding of the effectiveness of exercise to influence hormones that mediate appetite and satiety.