Lung Disease in Chinese Textile Workers

中国纺织工人的肺部疾病

• 批准号: 8235169
• 负责人: David C Christiani
• 金额: $ 47.67万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8235169
• 关键词: Lung; Disease; Chinese; Textile; Workers

DESCRIPTION (provided by applicant): The goal of this competing continuation is to complete a 30-year longitudinal study of a stable population of cotton textile workers in Shanghai, China. This cohort has been evaluated for cotton dust and endotoxin exposure as well as pulmonary effects since 1981. This unique study remains the longest and largest prospective cohort study of textile workers to date, with an unusually high (> 80%) participation rate and a large proportion of non-smokers. To date, this study has enabled us to report dust and endotoxin-related pulmonary effects, including new insights on the effect of exposure cessation and the role of some candidate genes related to endotoxin exposure. However, scientific uncertainties remain. Specifically, for over five decades, controversy continues as to whether emphysema or chronic bronchitis is the basis of the observed airway obstruction. Prior autopsy studies on small numbers of deceased workers have been conflicting. With the advent of improved high resolution computed tomography (HRCT) since 2002, as well as validated automated techniques to quantify the degree of emphysema and airways disease present in an individual, this proposal represents an unusual opportunity to apply this innovative technology to this unique and well characterized cohort of cotton and silk textile workers. We propose to extend follow-up in our study to a 30 year sampling so that we may explore in vivo several data-intensive strategies to elucidate the biological processes involved in dust and endotoxin-related lung disease. Our first aim is to assess the relationship between respiratory health status and long term exposure to cotton dust and endotoxin, as well as evaluate the effect of removal of exposure in retired workers; our second aim is to perform HRCT of the chest in study cohort volunteers, both exposed and unexposed to dust/endotoxin and with/without respiratory disease to identify the structural basis for the observed lung impairment. Finally, in the third aim we will test additional candidate gene polymorphisms that may modulate the development of dust and endotoxin-related airways disease. Continued study of this unique cohort by our experienced group of investigators using a comprehensive and innovative approach will help us identify key biological basis underlying the development of occupationally-related airways disease from organic dust and endotoxin exposure. The study addresses respiratory disease in the health outcome cross-sectors portion of the NIOSH extramural program portfolio. PUBLIC HEALTH RELEVANCE: The goal of this competing continuation is to complete a 30-year longitudinal study of a stable population of cotton textile workers with the goals of determining the precise nature of the airways disease in workers exposed to vegetable dust and the associated bacterial endotoxins. We will also assess potential improvement in lung function after removal from exposure, as well as susceptibility factors for occupational airways disease among this population.

描述（由申请人提供）：这一竞争性延续项目的目标是完成对中国上海稳定的棉纺织工人群体的 30 年纵向研究。自 1981 年以来，该队列一直在评估棉尘和内毒素暴露以及肺部影响。这项独特的研究仍然是迄今为止最长、规模最大的纺织工人前瞻性队列研究，参与率异常高 (> 80%)，并且非吸烟者比例很大。迄今为止，这项研究使我们能够报告灰尘和内毒素相关的肺部影响，包括对停止暴露的影响以及与内毒素暴露相关的一些候选基因的作用的新见解。然而，科学上的不确定性仍然存在。具体而言，五十多年来，关于肺气肿或慢性支气管炎是否是所观察到的气道阻塞的基础的争论一直存在。此前对少数死亡工人进行的尸检研究一直存在矛盾。自 2002 年以来，随着改进的高分辨率计算机断层扫描 (HRCT) 的出现，以及用于量化个体肺气肿和气道疾病程度的经过验证的自动化技术，该提案提供了一个难得的机会，可以将这种创新技术应用于这一独特且特征明确的棉纺织工人群体。我们建议将我们的研究随访时间延长至 30 年采样，以便我们可以在体内探索几种数据密集型策略，以阐明与灰尘和内毒素相关的肺部疾病所涉及的生物过程。我们的首要目标是评估呼吸健康状况与长期接触棉尘和内毒素之间的关系，以及评估退休工人去除接触的效果；我们的第二个目标是对暴露和未暴露于灰尘/内毒素以及患有/不患有呼吸道疾病的研究队列志愿者进行胸部 HRCT，以确定观察到的肺损伤的结构基础。最后，在第三个目标中，我们将测试可能调节灰尘和内毒素相关气道疾病发展的其他候选基因多态性。我们经验丰富的研究人员小组使用全面和创新的方法对这一独特的队列进行持续研究，将有助于我们确定有机粉尘和内毒素暴露导致职业相关气道疾病发展的关键生物学基础。该研究涉及 NIOSH 校外项目组合中健康结果跨部门部分的呼吸系统疾病。 公共健康相关性：这一竞争性延续项目的目标是完成对稳定的棉纺织工人群体为期 30 年的纵向研究，目的是确定接触蔬菜粉尘和相关细菌内毒素的工人呼吸道疾病的确切性质。我们还将评估脱离暴露后肺功能的潜在改善，以及该人群职业性气道疾病的易感因素。