OPERATION AND MAINTENANCE OF A PROTEIN DATABASE SEARCH SERVER

蛋白质数据库检索服务器的运维

• 批准号: 8361358
• 负责人: ILAN VIDAVSKY
• 金额: $ 0.52万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361358
• 关键词: Amino Acid Sequence; Antigens; Autoimmune Diseases; Computer software; Diabetes Mellitus; Disease; Funding; Grant; Knowledge; Maintenance; Mass Spectrum Analysis; Muscle; National Center for Research Resources; Nature; Peptide Sequence Determination; Peptides; Principal Investigator; Printing; Protein Databases; Protein Sequence Analysis; Proteins; Research; Research Infrastructure; Resources; Services; Source; Spectrum Analysis; United States National Institutes of Health; biomedical resource; cost; fighting; foot; operation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Servers with MASCOT software are used to analyze peptide and protein sequences for many reaserch and collaborative projects. For example we analyze peptide mixtures or digested proteins by LC-MS/MS and submit the spectra for analysis to determine the sequences and protein origin of antigenic peptides and for the muscle proteom project. Knowledge of the nature of antigens can help fight autoimmune diseases like diabetes. The servers are being used for many other projects that include core projects like HDX and foot printing of proteins, collaborative projects on muscle waisiting and Alzhiemer disease and service for protein identifications.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 配备MASCOT软件的服务器可用于许多研究和合作项目的肽和蛋白质序列分析。例如，我们通过LC-MS/MS分析肽混合物或消化的蛋白质，并提交光谱进行分析，以确定抗原肽的序列和蛋白质来源，并用于肌肉蛋白质组项目。了解抗原的性质有助于对抗糖尿病等自身免疫性疾病。 这些服务器正在用于许多其他项目，包括HDX和蛋白质足迹等核心项目，肌肉waisiting和Alzhiemer疾病的合作项目以及蛋白质鉴定服务。