OPERATION AND MAINTENANCE OF A PROTEIN DATABASE SEARCH SERVER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 配备MASCOT软件的服务器可用于许多研究和合作项目的肽和蛋白质序列分析。例如，我们通过LC-MS/MS分析肽混合物或消化的蛋白质，并提交光谱进行分析，以确定抗原肽的序列和蛋白质来源，并用于肌肉蛋白质组项目。了解抗原的性质有助于对抗糖尿病等自身免疫性疾病。 这些服务器正在用于许多其他项目，包括HDX和蛋白质足迹等核心项目，肌肉waisiting和Alzhiemer疾病的合作项目以及蛋白质鉴定服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Servers with MASCOT software are used to analyze peptide and protein sequences for many reaserch and collaborative projects. For example we analyze peptide mixtures or digested proteins by LC-MS/MS and submit the spectra for analysis to determine the sequences and protein origin of antigenic peptides and for the muscle proteom project. Knowledge of the nature of antigens can help fight autoimmune diseases like diabetes. The servers are being used for many other projects that include core projects like HDX and foot printing of proteins, collaborative projects on muscle waisiting and Alzhiemer disease and service for protein identifications.