TOXICOLOGICAL EFFECTS OF QUINONES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 含有酚类部分的物质通常被代谢成对苯二酚，这些对苯二酚的高活性不仅使它们难以研究，而且可能对它们的毒性负责。这些前体中的一些对健康有明显的好处，一些对苯二酚本身用于癌症治疗，而另一些是有害的。例如，饮食中摄入植物雌激素染料木素(Genistein，Gen)似乎对乳腺癌(BC)起到了预防作用，而长期接触化学相似的哺乳动物雌激素显然与BC的发病率增加有关。虽然两者都可以被代谢成反应性的苯二酚，但儿茶酚雌激素苯二酚(CEQs)通过氧化还原循环和/或通过Michael加成来净化DNA来修饰DNA。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Substances containing a phenolic moiety are often metabolized to quinones whose high reactivity not only makes them difficult to study but may also be responsible for their toxicity. Some of these precursors have clear health benefits, and some quinones themselves are used in cancer therapy, whereas others are deleterious. For example, dietary intake of phytoestrogen, genistein (Gen), seems to play a preventive role in breast cancer (BC) whereas prolonged exposure to chemically similar mammalian estrogens is clearly associated with elevated incidence of BC. Although both can be metabolized to reactive quinones, the catechol estrogen quinones (CEQs) modify DNA by redox cycling and/or depurination via a Michael addition.