Cross Region Neural Computation Subserving Attention

注意力对于我们的意识体验是非常重要的。不能集中注意力或转移注意力， 破坏性，并可能导致神经和精神疾病，如注意力缺陷， 多动症（ADHD）、诵读困难和精神分裂症。Desimone实验室和其他人的实验 已经表明注意力改变了许多视觉区域的神经活动， 地区越来越多的证据表明，存在自上而下的调节机制， 关注然而，这些效应背后的精确神经回路在很大程度上是未知的，它仍然存在。 难以在特定神经回路或细胞类型的活动之间建立因果关系， 行为和病理。因此，我将开发使用这些技术来激活和 沉默特定类型的神经元与毫秒的时间尺度精度，与此执行时间分辨 特定前额叶神经活动模式在自上而下中介中的必要性和充分性分析 控制注意力。

Attention is highly critical tp our conscious experience. A failure to focus or to shift attention can be devastating, and may contribute to neurological and psychiatric diseases such as attention deficit hyperactivity disorder (ADHD), dyslexia, and schizophrenia. Experiments from the Desimone lab and others have shown that attention alters neural activity in many visual areas and synchronizes activity across brain regions. There is increasing evidence for the presence of top-down modulatory mechanisms mediating attention. However, the precise neural circuitry underlying these effects is largely unl<nown, and it remains difficult to establish causal linl<s between activities in specific neural circuits or cell types, and emergent behaviors and pathologies. Accordingly, I will develop the use ofthe technologies for activating and silencing specific types of neurons with millisecond-timescale precision, with which to perform a timeresolved analysis of necessity and sufficiency of specific prefrontal neural activity patterns in mediating topdown control of attention.