THE PRIMATE EMBRYO GENE EXPRESSION RESOURCE
灵长类胚胎基因表达资源
基本信息
- 批准号:7959035
- 负责人:
- 金额:$ 7.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-05-01 至 2010-04-30
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelBasic ScienceCaliforniaCellsClinicalComputer Retrieval of Information on Scientific Projects DatabaseDatabasesDot ImmunoblottingEmbryoEmbryologyEvaluationFertilizationFundingGene ExpressionGrantIn VitroInstitutionLibrariesMacaca mulattaModelingMolecularOocytesOvarianPrimatesProceduresResearchResearch PersonnelResourcesSamplingScientistSourceStagingStem cellsTrainingUnited States National Institutes of HealthblastocystcDNA Libraryclinical effectclinical practicecosthatchingin vivonoveltoolweb site
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The Primate Embryo Gene Expression Resource permits the rapid and cost-effective study of gene expression in primate oocytes and preimplantation embryos using the rhesus monkey as the primary model organism. PREGER contains over 200 informative samples representing GV-stage oocytes, MIIstage oocytes, embryos at the 1-cell through hatched blastocyst stages, obtained using different combinations of in vitro or in vivo maturation, fertilization, and culture. The resource also contains stem cells and ovarian cells. This extensive and valuable sample set permits analyses of gene expression related to understanding basic primate embryology, as well as potential effects of clinical procedures on embryo quality using a primate model. Dot blots for expression analysis, cDNA libraries, probes, and other tools in PREGER can be distributed to other scientists, providing unprecedented opportunities for molecular studies in primate embryos. The libraries can be employed for a myriad of other purposes. The resource also includes a web site and online database. Most recently, the resource has incorporated an annual molecular embryology training course. The resource will facilitate basic research, and may support novel clinical approaches, e.g., in the evaluation of embryo quality. The proposed activities will at once maintain and expand the resource, produce new and fundamental basic information about primate embryos, and produce novel molecular approaches that may be useful in clinical practice.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
灵长类动物胚胎基因表达资源允许使用恒河猴作为主要模式生物快速和成本效益的灵长类动物卵母细胞和植入前胚胎的基因表达研究。PREGER包含超过200个信息样本,代表GV期卵母细胞、MII期卵母细胞、1细胞至孵化囊胚期的胚胎,使用体外或体内成熟、受精和培养的不同组合获得。 该资源还包含干细胞和卵巢细胞。 这一广泛而有价值的样本集允许分析与理解基本灵长类动物胚胎学相关的基因表达,以及使用灵长类动物模型临床程序对胚胎质量的潜在影响。PREGER中用于表达分析的斑点印迹、cDNA文库、探针和其他工具可以分发给其他科学家,为灵长类动物胚胎的分子研究提供了前所未有的机会。这些库可以用于无数其他目的。该资源还包括一个网站和在线数据库。 最近,该资源已纳入年度分子胚胎学培训课程。 该资源将促进基础研究,并可能支持新的临床方法,例如,评估胚胎质量。拟议的活动将立即维持和扩大资源,产生有关灵长类动物胚胎的新的和基本的基本信息,并产生可能在临床实践中有用的新的分子方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Keith E Latham其他文献
Keith E Latham的其他文献
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{{ truncateString('Keith E Latham', 18)}}的其他基金
Conditional knockout effects of SMCHD1 in oocytes and embryos
卵母细胞和胚胎中 SMCHD1 的条件性敲除效应
- 批准号:
10228093 - 财政年份:2020
- 资助金额:
$ 7.12万 - 项目类别:
Conditional knockout effects of SMCHD1 in oocytes and embryos
卵母细胞和胚胎中 SMCHD1 的条件性敲除效应
- 批准号:
10083824 - 财政年份:2020
- 资助金额:
$ 7.12万 - 项目类别:
Epigenetic links from oocyte to postnatal health
卵母细胞与产后健康的表观遗传联系
- 批准号:
8626607 - 财政年份:2013
- 资助金额:
$ 7.12万 - 项目类别:
Epigenetic links from oocyte to postnatal health
卵母细胞与产后健康的表观遗传联系
- 批准号:
9189638 - 财政年份:2013
- 资助金额:
$ 7.12万 - 项目类别:
Nuclear Reprogramming and Phenotype in Cloned Embryos
克隆胚胎中的核重编程和表型
- 批准号:
8712721 - 财政年份:2013
- 资助金额:
$ 7.12万 - 项目类别:
Genetic and Molecular Approach to Identify Ooplasm Reprogramming Factors
鉴定卵质重编程因子的遗传和分子方法
- 批准号:
7814932 - 财政年份:2009
- 资助金额:
$ 7.12万 - 项目类别:
Genetic and Molecular Approach to Identify Ooplasm Reprogramming Factors
鉴定卵质重编程因子的遗传和分子方法
- 批准号:
7944163 - 财政年份:2009
- 资助金额:
$ 7.12万 - 项目类别:
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