AutoSense: Quantifying Exposures to Addictive Substances and Psychosocial Stress

AutoSense：量化成瘾物质暴露和心理压力

• 批准号: 8115664
• 负责人: Santosh Kumar
• 金额: $ 10.65万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-14 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115664
• 关键词: Alcohol or Other Drugs use; Alcohols; Antineoplastic Agents; Behavior; Biochemical; Biosensor; Blood Pressure; Blood alcohol level measurement; Body Temperature; Categories; Clinical; Collection; Computer Assisted; Computer software; Data; Data Collection; Development; Devices; Disease; Drug Addiction; Environment; Epinephrine; Error Sources; Etiology; Exposure to; Frequencies; Future; Galvanic Skin Response; Genetic; Goals; Heart Diseases; Heart Rate; Hormones; Human; Individual; Intercellular Fluid; Intervention; Knowledge; Laboratories; Learning; Life; Life Style; Measurement; Measures; Memory; Mental Depression; Methods; Microprocessor; Monitor; Nicotine; Participant; Patient Monitoring; Patient Self-Report; Pattern; Personal Digital Assistant; Physiological; Physiological Processes; Procedures; Process; Psychosocial Stress; Public Health; Research Personnel; Research Project Grants; Respiration; Rest; Sampling; Skin Temperature; Stress; System; Technology; Testing; Time; Update; Validity and Reliability; Wireless Technology; Work; acute stress; alcohol exposure; alcohol measurement; alcohol response; base; computerized data processing; experience; field study; human disease; improved; indexing; informant; innovative technologies; new technology; portability; programs; relationship abuse; research study; response; sensor; software development; success; tool; transmission process

DESCRIPTION (provided by applicant): Repeated exposures to addictive substances and psychosocial stress are associated with myriad human diseases (e.g., cancer, drug addiction, heart disease, and depression) of tremendous public health burden. However, our progress in the understanding of how exposures to addictive substances and psychosocial stress interact with genetic factors in the etiology of prevalent human diseases is hindered by the lack of technology to collect precise, accurate and objective data to measure personal exposure to both addictive substances and to psychosocial stress, in real time and in an individual's natural environment. In this trans-disciplinary research project, we propose to develop and validate a new field-deployable tool called AutoSense, to measure personal exposure to alcohol and psychosocial stress by leveraging recent developments in wireless sensor network technology, and innovative approaches in the use of wearable sensors for the non-invasive, real-time, and continuous biochemical assessment of human interstitial fluid. AutoSense will be based on a highly versatile, portable, affordable, and de-facto wireless sensor network platform with a microprocessor and wireless transceiver, called Mote, which is already being used in several embedded sensing applications, including ambulatory patient monitoring. There are three specific aims of this project. First, we propose to integrate an existing ISF alcohol sensor in AutoSense. This sensor developed by SpectRx Inc. non-invasively collects ISF samples to detect levels of alcohol present in a subject's body and automatically calibrates to discern changes in blood alcohol levels. We will also integrate several other existing physiological sensors on the Mote to assess physiological responses related to stress, including skin temperature, skin conductance, respiration rate, and heart rate. Second, we will develop new software to collect and process physiological data on alcohol and stress exposure, to securely transmit the collected data via wireless channel on a real-time basis, and to command, control, and update field deployed AutoSense devices remotely. Third, we will conduct rigorous lab and field studies to validate the AutoSense device. The goals of the lab study will be to establish the validity of using the ISF-based alcohol sensor and other physiological sensors as measures of biochemical responses to alcohol exposure and stress. The goals of the field study will be to demonstrate the feasibility and reliability of field deployment. Relevance: The AutoSense device will enable researchers to quantify personal exposure to addictive substances and psychosocial stress, as experienced by individuals in real-life situations. Such a capability will advance our understanding of how exposures to addictive substances and psychosocial stress interact with genetic factors in the etiology of prevalent human diseases of tremendous public health burden.

描述（由申请人提供）：反复暴露于成瘾物质和心理社会压力与无数人类疾病有关（例如，癌症、毒瘾、心脏病和抑郁症）的巨大公共卫生负担。然而，由于缺乏技术来收集精确、准确和客观的数据，无法在真实的时间和个人的自然环境中衡量个人接触成瘾物质和心理社会压力的情况，我们在了解接触成瘾物质和心理社会压力如何与人类流行疾病病因学中的遗传因素相互作用方面的进展受到阻碍。在这个跨学科的研究项目中，我们建议开发和验证一种新的现场部署工具，称为AutoSense，利用无线传感器网络技术的最新发展来测量个人暴露于酒精和心理压力，以及使用可穿戴传感器进行非侵入性，实时和连续的人体间质液生化评估的创新方法。AutoSense将基于一个高度通用、便携、经济实惠的无线传感器网络平台，该平台具有微处理器和无线收发器，称为Mote，该平台已用于多个嵌入式传感应用，包括动态患者监测。该项目有三个具体目标。首先，我们建议将现有的ISF酒精传感器集成到AutoSense中。该传感器由SpectRx Inc.非侵入性地收集ISF样本，以检测受试者体内的酒精水平，并自动校准以辨别血液酒精水平的变化。我们还将在Mote上集成其他几个现有的生理传感器，以评估与压力相关的生理反应，包括皮肤温度、皮肤电导、呼吸率和心率。其次，我们将开发新的软件来收集和处理酒精和压力暴露的生理数据，通过无线信道实时安全地传输收集的数据，并远程命令，控制和更新现场部署的AutoSense设备。第三，我们将进行严格的实验室和现场研究，以验证AutoSense设备。实验室研究的目标将是建立使用基于ISF的酒精传感器和其他生理传感器作为对酒精暴露和压力的生化反应的测量的有效性。实地研究的目的是证明实地部署的可行性和可靠性。相关性：AutoSense设备将使研究人员能够量化个人在现实生活中所经历的成瘾物质和心理社会压力的个人暴露。这种能力将促进我们对成瘾物质和心理社会压力的暴露如何与造成巨大公共卫生负担的流行人类疾病的病因学中的遗传因素相互作用的理解。