Molecular typing and epidemiology of Bordetella pertussis in Australia
澳大利亚百日咳博德特氏菌的分子分型和流行病学
基本信息
- 批准号:nhmrc : 455308
- 负责人:
- 金额:$ 36.85万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:NHMRC Project Grants
- 财政年份:2007
- 资助国家:澳大利亚
- 起止时间:2007-01-01 至 2009-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Pertussis, commonly known as whooping cough, is an acute respiratory disease caused by Bordetella pertussis. Despite more than half a century of vaccination, pertussis has remained endemic in Australia, causing epidemic outbreaks every 3 to 4 years. Indeed the incidence has been increasing in recent years with over 11,000 cases notified in 2005.Pertussis is the commonest of all vaccine preventable diseases targeted by the Australian standard vaccination schedule. To control pertussis, appropriate epidemiological surveillance must be implemented to monitor the circulating B. pertussis strains and emergence of any new strains, in particular those that escape the protection by vaccines. This project will use a novel genomic comparison approach to find variation known as single nucleotide polymorphisms (SNP) present around the genome. We will use these SNPs to analyse a large collection of Australian and worldwide isolates to identify those SNPs most suitable for typing and determine the optimal number of SNPs needed for discrimination. A standardized, consistent and reliable typing method for strain identification will be established. We will further develop an integrated method for detecting known variation in the genes encoding the five acellular vaccine antigens. A combined method for strain identification and detection of antigenic variation will then be developed for culture-independent typing, enabling identification of the strain infecting an individual directly from a clinical sample without the need for culture. This study will establish molecular methods for surveillance of pertussis in Australia, essential for further improvement of acellular pertussis vaccines and public health control measures.
百日咳,俗称百日咳,是由百日咳博德特氏菌引起的一种急性呼吸道疾病。尽管疫苗接种已进行了半个多世纪,但百日咳在澳大利亚仍然流行,每 3 至 4 年就会爆发一次流行病。事实上,近年来该病的发病率一直在增加,2005 年通报的病例已超过 11,000 例。百日咳是澳大利亚标准疫苗接种计划所针对的所有疫苗可预防疾病中最常见的一种。为了控制百日咳,必须实施适当的流行病学监测,以监测循环的百日咳杆菌菌株和任何新菌株的出现,特别是那些逃脱疫苗保护的菌株。该项目将使用一种新颖的基因组比较方法来发现基因组周围存在的称为单核苷酸多态性(SNP)的变异。我们将使用这些 SNP 来分析大量澳大利亚和世界各地的分离株,以确定最适合分型的 SNP,并确定区分所需的最佳 SNP 数量。建立标准化、一致、可靠的菌株鉴定分型方法。我们将进一步开发一种综合方法来检测编码五种非细胞疫苗抗原的基因中的已知变异。然后将开发一种用于菌株鉴定和抗原变异检测的组合方法,用于独立于培养物的分型,从而能够直接从临床样本中鉴定感染个体的菌株,而无需培养。这项研究将建立澳大利亚百日咳监测的分子方法,这对于进一步改进无细胞百日咳疫苗和公共卫生控制措施至关重要。
项目成果
期刊论文数量(0)
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{{ truncateString('A/Pr Ruiting Lan', 18)}}的其他基金
Genomics dissection and prevention of bacterial transmission events
基因组学解析和细菌传播事件的预防
- 批准号:
nhmrc : 1102170 - 财政年份:2016
- 资助金额:
$ 36.85万 - 项目类别:
Project Grants
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- 批准号:
nhmrc : 457472 - 财政年份:2007
- 资助金额:
$ 36.85万 - 项目类别:
NHMRC Project Grants
Origins and relationships of Shigella and enteroinvasive Escherichia coli
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- 资助金额:
$ 36.85万 - 项目类别:
NHMRC Project Grants
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